Association Between Preconception Multivitamin Use and the Risk of Preeclampsia/High Blood Pressure in Pregnant Women

摘要

Gestational Hypertension and Preeclampsia are significant causes of morbidity and mortality among pregnant women and neonates. This study examined the relationship between multivitamin use and incidence of reported high blood pressure or preeclampsia using data from the 2007 Oregon State Pregnancy Risk Assessment Monitoring System (PRAMS). Overall there were n=1894 women included in the study. Women were asked two to four months after delivery to report their multivitamin or prenatal vitamin usage in the month prior to conception and were categorized as daily users, or less than daily users. The unadjusted prevalence of high blood pressure or preeclampsia was 13.4% among daily users and 11.9% among nonusers. The study showed that the association between multivitamin use and preeclampsia was modified by BMI. Upon adjustment for parity, diabetes, pregnancy intent, abuse, and maternal age, analysis stratified by maternal pre-pregnancy BMI revealed a borderline significant protective effect among daily multivitamin users with a BMI less than 30 (OR 0.48, 95% CI [0.22,1.04]), and a significant risk for women with a BMI greater than 30 (OR 2.74, 95% CI [1.02,7.40]). This study showed the potential impact of multivitamin on preeclampsia among obese and non-obese women. Additional investigations are needed to examine the association and potential biologic mechanisms for this association need to be explored.