Corrigendum: Identification of cerebral metal ion imbalance in the brain of ageing octodon degus Front. Aging Neurosci., 9, (2017) (66) DOI: 10.3389/fnagi.2017.00066

摘要

© 2017 Braidy, Poljak, Marjo, Rutlidge, Rich, Jugder, Jayasena, Inestrosa and Sachdev. Due to a misunderstanding, the O. degus brain specimen used in the study were obtained from the animal facility of the Pontificia Universidad Catholic University of Chile, not the animal facility of the University of Valparaiso as previously stated in the article. Therefore, in the animal methods section, the correct paragraph should read: Octodon degus were obtained from a breeding colony at the animal facility of the Pontifical Catholic University of Chile and maintained in a controlled temperature room (23 ± 1°C), under a 12:12 h light/dark cycle, with water and food provided ad libitum. At the time of this study, 16 male O. degus were grouped by age, from 12 to 36 months of age (n = 8 per group). Ages were selected to represent the development of AD-like pathology (36 months). All efforts were made to minimize animal discomfort and stress while also limiting the number of animals used. Aged animals were anesthetized with Equitesin (2.5 ml/kg, i.p.) and injected with heparin (4 USP/kg, i.p.). Afterward, brains were surgically removed from their skulls and frozen in isopentane at -78.5°C. All procedures were conducted according to animal protocols approved by the Institutional Animal Care and Use Committee at the Pontifical Catholic University of Chile.