首页> 外文OA文献 >EFFECTS OF AMG 145, A FULLY HUMAN MONOCLONAL ANTIBODY AGAINST PCSK9, ON LOW-DENSITY LIPOPROTEIN CHOLESTEROL IN SUBJECTS TAKING STATINS: A PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, ASCENDING MULTIPLE-DOSE STUDY

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EFFECTS OF AMG 145, A FULLY HUMAN MONOCLONAL ANTIBODY AGAINST PCSK9, ON LOW-DENSITY LIPOPROTEIN CHOLESTEROL IN SUBJECTS TAKING STATINS: A PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, ASCENDING MULTIPLE-DOSE STUDY

机译：抗PCSK9的完全人类单克隆抗体AMG 145对服用他汀类药物的低密度脂蛋白胆固醇的影响：第1阶段，随机，双盲，放置控制，递增多剂量研究

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Dias Clapton; Shaywitz Adam; Cooke Blaire; Uy Stephen; Emery Maurice; Gibbs John; Crispino Caroline; Smirnakis Karen; Smith Brian; Gao Bing; Wasserman Scott; Stein Evan;
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1. Effects of AMG 145 on low-density lipoprotein cholesterol levels: Results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins [J] . DiasC.S., ShaywitzA.J., WassermanS.M., Journal of the American College of Cardiology . 2012,第19期

机译：AMG 145对低密度脂蛋白胆固醇水平的影响：在健康志愿者和高胆固醇血症受试者中对他汀类药物进行的2项随机，双盲，安慰剂对照，递增剂量1期研究的结果
2. AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of national cholesterol education program-adult treatment panel III low-density lipoprotein cholesterol goals among high-risk patients: An analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonaL antibody inhibition combined with statin thErapy-thrombolysis in myocardial infarction 57) [J] . DesaiN.R., GiuglianoR.P., ZhouJ., Journal of the American College of Cardiology . 2014,第5期

机译：AMG 145是针对PCSK9的单克隆抗体，可促进高危患者中国家胆固醇教育计划-成人治疗小组III低密度脂蛋白胆固醇目标的实现：来自LAPLACE-TIMI 57试验的分析（使用PCSK9 monoclonaL进行LDL-C评估抗体抑制联合他汀类药物治疗心肌梗塞溶栓57）
3. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: The reduction of LDL-C with PCSK9 inhibition in heterozygous familial hypercholesterolemia disorder (RUTHERFORD) randomized trial [J] . RaalF., ScottR., SomaratneR., Circulation: An Official Journal of the American Heart Association . 2012,第20期

机译：AMG 145的低密度脂蛋白胆固醇降低作用，对杂合子家族性高胆固醇血症患者的前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型丝氨酸蛋白酶的单克隆抗体：PCSK9抑制可降低LDL-C对杂合子家族性高胆固醇血症（RUTHERFORD）的影响试用
4. A Phase I, Double-Blind, Randomized, Dose Escalating Crossover Study ofan Oral Formulation of Human Growth Hormone in Healthy Male Volunteers [C] . Steven M. Dinh, Puchun Liu, Ehud Arbit, Controlled Release Society annual meeting . 2004

机译：健康男性志愿者中人类生长激素口服制剂的I期，双盲，随机，剂量递增交叉研究
5. A Phase 1B, Double-blind, Placebo-controlled, Parallel-group, Multi-dose Study of the Pharmacodynamics of NGM282 on Colonic Transit, Bile Acid Homeostasis and Fecal Fat in Subjects with Functional Constipation [D] . Oduyebo, Ibironke. 2018

机译：1B，双盲，安慰剂控制，并行组，NGM282对结肠转运，胆汁酸痛和患者功能性便秘的粪便脂肪的药物动力学的多剂量研究
6. Extended report: Mavrilimumab a human monoclonal antibody targeting GM-CSF receptor-α in subjects with rheumatoid arthritis: a randomised double-blind placebo-controlled phase I first-in-human study [O] . Gerd R Burmester, Eugen Feist, Matthew A Sleeman, -1

机译：扩展报告：类风湿关节炎受试者中针对GM-CSF受体-α的人单克隆抗体Mavrilimumab：一项随机双盲安慰剂对照I期首次在人体中的研究
7. Effects of AMG 145 on Low-Density Lipoprotein Cholesterol Levels Results From 2 Randomized, Double-Blind, Placebo-Controlled, Ascending-Dose Phase 1 Studies in Healthy Volunteers and Hypercholesterolemic Subjects on Statins [O] . Dias Clapton S., Shaywitz Adam J., Wasserman Scott M., 2012

机译：AMG 145对低密度脂蛋白胆固醇水平的影响来自两项针对他汀类药物的健康志愿者和高胆固醇血症受试者的2项随机，双盲，安慰剂对照，递增剂量的1期研究结果

EFFECTS OF AMG 145, A FULLY HUMAN MONOCLONAL ANTIBODY AGAINST PCSK9, ON LOW-DENSITY LIPOPROTEIN CHOLESTEROL IN SUBJECTS TAKING STATINS: A PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, ASCENDING MULTIPLE-DOSE STUDY

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