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Prasugrel 5 mg in the Very Elderly Attenuates Platelet Inhibition But Maintains Noninferiority to Prasugrel 10 mg in Nonelderly Patients The GENERATIONS Trial, A Pharmacodynamic and Pharmacokinetic Study in Stable Coronary Artery Disease Patients

机译：老年人中的普拉格雷5 mg可以减轻血小板抑制作用，但与非普拉格雷10 mg相比，在老年患者中保持不逊色GENERATIONS试验，一种稳定的冠状动脉疾病患者的药效动力学和药代动力学研究

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Erlinge David; Gurbel Paul A.; James Stefan; Lindahl Tomas L.; Svensson Peter; Ten Berg Jurrien M.; Foley David P.; Wagner Henrik; Brown Patricia B.; Luo Junxiang; Zhou Chunmei; Moser Brian A.; Jakubowski Joseph A.; Small David S.; Winters Kenneth J.; Angiolillo Dominick J.;
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1. Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: The GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients [J] . ErlingeD., GurbelP.A., JamesS., Journal of the American College of Cardiology . 2013,第7期

机译：Prasugrel 5毫克在非常老年衰减的血小板抑制，但在非角性患者中保持不血清血清10毫克的血小板10毫克：几代试验，稳定冠状动脉疾病患者的药物动力学和药代动力学研究
2. Prasugrel 5 mg in the very elderly attenuates platelet inhibition but maintains noninferiority to prasugrel 10 mg in nonelderly patients: The GENERATIONS trial, a pharmacodynamic and pharmacokinetic study in stable coronary artery disease patients [J] . ErlingeD., GurbelP.A., JamesS., Journal of the American College of Cardiology . 2013,第7期

机译：老年患者中的普拉格雷5 mg减弱了血小板抑制作用，但在非老年患者中维持了普拉格雷10 mg的自卑性：GENERATIONS试验，在稳定的冠状动脉疾病患者中进行的药效学和药代动力学研究
3. The effect of CYP2C19 gene polymorphisms on the pharmacokinetics and pharmacodynamics of prasugrel 5-mg, prasugrel 10-mg and clopidogrel 75-mg in patients with coronary artery disease. [J] . P A Gurbel, T O Bergmeijer, U S Tantry, Thrombosis and Haemostasis: Journal of the International Society on Thrombosis and Haemostasis . 2014,第3期

机译：CYP2C19基因多态性对冠心病患者5毫克普拉格雷，10毫克普拉格雷和75毫克氯吡格雷的药代动力学和药效学的影响。
4. The Long-Term Clinical Results of a Platelet Glycoprotein Ilb/IIIa Receptor Blocker (Abciximab: ReoPro~R)-Coated Stent in Patients with Coronary Artery Disease [C] . W. Kim, M.H. Jeong, Y.J. Hong, International Congress on Thrombosis . 2004

机译：冠状动脉疾病患者的血小板糖蛋白ILB / IIIA受体阻滞剂（Abciximab：Reopro〜R）涂层支架的长期临床结果
5. Predictors of early saphenous vein graft patency, platelet hyper-reactivity and aspirin-insensitive thromboxane generation in patients undergoing coronary artery bypass graft surgery. [D] . Nazarian, Susanna M. 2009

机译：冠状动脉搭桥手术患者早期大隐静脉移植物通畅性，血小板高反应性和阿司匹林不敏感血栓烷生成的预测指标。
6. Editors Choice: A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 Trial [O] . Dominick J. Angiolillo, Juan Jose Badimon, Jorge F. Saucedo, -1

机译：编辑推荐：普拉格雷与大剂量氯吡格雷在2型糖尿病和冠状动脉疾病患者中的药效比较：糖尿病MellitUS（OPTIMUS）-3试验的最佳抗血小板治疗结果
7. Prasugrel 5 mg in the Very Elderly Attenuates Platelet Inhibition But Maintains Noninferiority to Prasugrel 10 mg in Nonelderly Patients The GENERATIONS Trial, A Pharmacodynamic and Pharmacokinetic Study in Stable Coronary Artery Disease Patients [O] . Department of Cardiology, Lund University, Lund, Sweden ( host institution ), Erlinge, David ( author ), Gurbel, Paul A. ( author ), 2013

机译：老年人中的普拉格雷5 mg可减轻血小板抑制作用，但与非普拉格雷10 mg相比，在非老年患者中保持不逊色GENERATIONS试验，稳定的冠状动脉疾病患者的药效和药代动力学研究

Prasugrel 5 mg in the Very Elderly Attenuates Platelet Inhibition But Maintains Noninferiority to Prasugrel 10 mg in Nonelderly Patients The GENERATIONS Trial, A Pharmacodynamic and Pharmacokinetic Study in Stable Coronary Artery Disease Patients

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