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Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

机译：糖尿病基因编码瘦素受体的证据：鉴定db / db小鼠中的瘦素受体基因的突变。

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Chen Hong; Charlat Olga; Tartaglia Louis A; Woolf Elizabeth A; Weng Xun; Ellis Stephen J; Lakey Nathan D; Culpepper Janice; More Karen J; Breitbart Roger E; Duyk Geoffrey M; Tepper Robert I; Morgenstern Jay P;
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1. Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice [J] . Streamson C. Chua, Shun Mei Liu, Qiong Li, American Journal of Physiology . 2004,第3aPta1期

机译：瘦素受体缺陷的转基因互补。二。瘦素受体转基因剂量增加对lepr-db / db小鼠的肥胖/糖尿病和受精/泌乳的影响
2. A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice [J] . Federica Piattini, Christelle Le Foll, Jan Kisielow, Molecular Metabolism . 2019,第20期

机译：自发性瘦素受体点突变会导致肥胖，并差异性影响下丘脑核中的瘦素信号传导，从而导致与db / db小鼠不同的代谢功能障碍
3. A novel and quick PCR-based method to genotype mice with a leptin receptor mutation (db/db mice) [J] . Bao-yu PENG, Qiang WANG, Yan-hong LUO, 中国药理学报：英文版 . 2018,第001期

机译：一种新颖且快速的基于PCR的方法来鉴定具有瘦蛋白受体突变的小鼠（db / db小鼠）
4. Obesity-related mutations of leptin and melanocortin receptors [C] . Cecile Lubrano, Beatrice Dubern, Karine Clemen Colloque me?decine et recherche . 2006

机译：瘦素和黑素旋基因受体的肥胖相关突变
5. Potent anorexic and lipopenic effects of central leptin gene therapy are blocked by diet-induced obesity: Evidence for impaired leptin receptor expression/signal transduction in obesity and reversal by caloric restriction. [D] . Wilsey, Jared Timothy. 2003

机译：饮食诱导的肥胖症会阻止中央瘦素基因疗法的有效厌食症和脂肪减少症：肥胖症中瘦素受体表达/信号转导受损的证据以及受热量限制的逆转。
6. A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice [O] . Federica Piattini, Christelle Le Foll, Jan Kisielow, 2019

机译：自发性瘦素受体点突变导致肥胖并差异性影响下丘脑核中的瘦素信号传导从而导致不同于db / db小鼠的代谢功能障碍
7. A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice [O] . Federica Piattini, Christelle Le Foll, Jan Kisielow, 2019

机译：自发性瘦素受体点突变导致肥胖症并差异地影响下丘脑中的瘦素信号传导，导致与DB / DB小鼠不同的代谢功能障碍

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Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

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