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Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

机译：人C9ORF72六核苷酸的扩增在BAC转基因小鼠中复制RNA病灶和二肽重复蛋白，但不发生神经退行性变

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Peters Owen M.; Cabrera Gabriela Toro; Tran Helene; Gendron Tania F.; McKeon Jeanne E.; Metterville Jake; Weiss Alexandra; Wightman Nicholas; Salameh Johnny; Kim Juhyun; Sun Huaming; Boylan Kevin B.; Dickson Dennis; Kennedy Zachary; Lin Ziqiang; Zhang Yong-Jie; Daughrity Lillian; Jung Chris; Gao Fen-Biao; Sapp Peter C.; Horvitz H. Robert; Bosco Daryl A.; Brown Solange P.; de Jong Pieter; Petrucelli Leonard; Mueller Christian; Brown Robert H.;
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1. Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice [J] . Peters Owen M., Cabrera Gabriela Toro, Tran Helene, Neuron . 2015,第5期

机译：人C9ORF72六核苷酸扩增可在BAC转基因小鼠中复制RNA病灶和二肽重复蛋白，但不发生神经退行性变
2. Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells [J] . Leskela Stina, Huber Nadine, Hoffmann Dorit, Biochimica et biophysica acta. Molecular cell research . 2021,第7期

机译：C9ORF72己核苷酸的表达重复膨胀导致RNA焦谱和二肽重复蛋白的形成，但不会影响神经元细胞中的自噬或蛋白酶体功能
3. A 30-unit hexanucleotide repeat expansion in C9orf72 induces pathological lesions with dipeptide-repeat proteins and RNA foci, but not TDP-43 inclusions and clinical disease [J] . Gami Priya, Murray Christina, Schottlaender Lucia, Acta Neuropathologica . 2015,第4期

机译：C9orf72中30个单位的六核苷酸重复扩增可诱导具有二肽重复蛋白和RNA病灶的病理性病变，但不会诱导TDP-43夹杂物和临床疾病
4. Overexpression of human amyloid precursor protein causes neurodegeneration and loss of synaptic proteins in transgenic Drosophila [C] . Sarantseva S., Bolshakova O., Timoshenko S., International Conference on Alzheimer's and Parkinson's Diseases . 2009

机译：人淀粉样蛋白前体蛋白的过度表达导致转基因果蝇中的神经变性和突触蛋白的丧失
5. Transcriptional Inhibition of (GGGGCC) c9orf72 Hexanucleotide Repeat Expansion in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis [D] . Kim, Yujin E. 2019

机译：在额颞痴呆和肌萎缩性侧索硬化中（GGGGCC）c9orf72六核苷酸重复扩展的转录抑制。
6. Expression of human C9ORF72 hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice [O] . Owen M. Peters, Gabriela Toro Cabrera, Helene Tran, -1

机译：在BAC转基因小鼠中人C9ORF72六核苷酸扩展的表达可复制RNA病灶和二肽重复蛋白但不会引起神经退行性变
7. Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice [O] . Peters, Owen M., Toro Cabrera, Gabriela, Tran, Helene, 2015

机译：人类C9ORF72六核苷酸扩增再生BaC转基因小鼠中的RNa病灶和二肽重复蛋白但不是神经变性

Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

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