首页> 外文OA文献 >A Simian Human Immunodeficiency Virus with a Nonfunctional Vpu (ΔvpuSHIVKU-1bMC33) Isolated from a Macaque with NeuroAIDS Has Selected for Mutations in Env and Nef That Contributed to Its Pathogenic Phenotype

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A Simian Human Immunodeficiency Virus with a Nonfunctional Vpu (ΔvpuSHIVKU-1bMC33) Isolated from a Macaque with NeuroAIDS Has Selected for Mutations in Env and Nef That Contributed to Its Pathogenic Phenotype

机译：从具有神经性艾滋病的猕猴中分离出具有非功能性Vpu（ΔvpuSHIVKU-1bMC33）的猿猴人类免疫缺陷病毒已选择了Env和Nef突变的致病表型。

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Singh Dinesh K.; McCormick Coleen; Pacyniak Erik; Lawrence Kathi; Dalton Steven B.; Pinson Dave M.; Sun Francis; Berman Nancy E.J.; Calvert Meredith; Gunderson Robert S.; Wong Scott W.; Stephens Edward B.;
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1. A simian human immunodeficiency virus with a nonfunctional Vpu (trianglevpuSHIV(KU-1bMC33)) isolated from a macaque with NeuroAIDS has selectedfor mutations in Env and Nef that contributed to its pathogenic phenotype [J] . Singh DK, McCormick C, Pacyniak E, Virology . 2001,第1期

机译：从具有NeuroAIDS的猕猴中分离出具有非功能性Vpu（trianglevpuSHIV（KU-1bMC33））的猿猴人类免疫缺陷病毒，已选择Env和Nef突变来致病性表型
2. Deletion of the vpu sequences prior to the env in a simian-human immunodeficiency virus results in enhanced Env precursor synthesis but is less pathogenic for pig-tailed macaques. [J] . Stephens EB, McCormick C, Pacyniak E, Virology . 2002,第2期

机译：在猿猴-人类免疫缺陷病毒中，在env之前删除vpu序列会增强Env前体的合成，但对猪尾猕猴的致病性较小。
3. Chronology of genetic changes in the vpu, env, and Nef genes of chimeric simian-human immunodeficiency virus (strain HXB2) during acquisition of virulence for pig-tailed macaques. [J] . McCormick-Davis C, Zhao LJ, Mukherjee S, Virology . 1998,第2期

机译：猪尾猕猴毒力获得过程中嵌合猿猴-人免疫缺陷病毒（HXB2株）的vpu，env和Nef基因遗传变化的时间顺序。
4. The role of the transmembrane and cytoplasmic domains of the VPU protein of human immunodeficiency virus type 1 (HIV-1) in the acute CD4+ T cell loss and disease in the simian human immunodeficiency virus (SHIV)/macaque model. [D] . Hout, David Richard. 2006

机译：人类免疫缺陷病毒1型（HIV-1）的VPU蛋白的跨膜和胞质域在猿猴人类免疫缺陷病毒（SHIV）/猕猴模型的急性CD4 + T细胞丧失和疾病中的作用。
5. Some Human Immunodeficiency Virus Type 1 Vpu Proteins Are Able To Antagonize Macaque BST-2 In Vitro and In Vivo: Vpu-Negative Simian-Human Immunodeficiency Viruses Are Attenuated In Vivo [O] . Masashi Shingai, Takeshi Yoshida, Malcolm A. Martin, 2011

机译：某些1型人类免疫缺陷病毒Vpu蛋白能够在体外和体内拮抗猕猴BST-2：Vpu阴性的猿猴-人类免疫缺陷病毒在体内具有减弱作用。
6. Deletion of the vpu Sequences prior to the env in a Simian–Human Immunodeficiency Virus Results in Enhanced Env Precursor Synthesis but Is Less Pathogenic for Pig-Tailed Macaques [O] . Stephens Edward B, McCormick Coleen, Pacyniak Erik, 2002

机译：在猿猴-人免疫缺陷病毒中，在env之前删除vpu序列会增强env前体的合成，但对猪尾猕猴的致病性较小

A Simian Human Immunodeficiency Virus with a Nonfunctional Vpu (ΔvpuSHIVKU-1bMC33) Isolated from a Macaque with NeuroAIDS Has Selected for Mutations in Env and Nef That Contributed to Its Pathogenic Phenotype

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