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Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics

机译：针对gp41 N七肽重复序列（NHR）卷曲螺旋引发的抗体可以中度效价中和HIV-1，但非中和抗体也可与NHR模拟物结合

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Nelson Josh D.; Kinkead Heather; Brunel Florence M.; Leaman Dan; Jensen Richard; Louis John M.; Maruyama Toshiaki; Bewley Carole A.; Bowdish Katherine; Clore G. Marius; Dawson Philip E.; Frederickson Shana; Mage Rose G.; Richman Douglas D.; Burton Dennis R.; Zwick Michael B.;
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1. Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics. [J] . Nelson JD, Kinkead H, Brunel FM, Virology . 2008,第1期

机译：针对gp41 N七肽重复序列（NHR）卷曲螺旋引发的抗体可以中度效价中和HIV-1，但非中和抗体也可以与NHR模拟物结合。
2. F(ab')2 fragment of a gp41 NHR-trimer-induced IgM monoclonal antibody neutralizes HIV-1 infection and blocks viral fusion by targeting the conserved gp41 pocket [J] . LuL., WeiM., ChenY., Microbes and infection . 2013,第13期

机译：gp41 NHR-三聚体诱导的IgM单克隆抗体的F（ab'）2片段通过靶向保守的gp41口袋来中和HIV-1感染并阻断病毒融合
3. Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naive human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth. [J] . Gustchina E, Louis JM, Frisch C Virology . 2009,第1期

机译：通过衍生自合成的天然人抗体文库并针对gp41的内部三聚体卷曲螺旋的单克隆Fab的CDR-H2环的靶向多样化，进行亲和力成熟，可以生产出具有改善的HIV-1中和力和广度的Fab。
4. Synthesis of HIV Gp41 Trimer Mimics Inducing Neutralizing Antibodies Based on Remodeling of Dynamic Structures of HIV-1 Envelope Proteins [C] . Wataru Nomera, Toru Nakahara, Chie Hashimoto American Peptide Symposium . 2011

机译：基于HIV-1包络蛋白动态结构的重塑诱导中和抗体的HIV GP41三聚体模拟物的合成
5. Two Sides to the Same Antibody: Assessing the Role of Neutralizing and Non-neutralizing Antibodies in Mother-to-child Transmission of HIV-1 [D] . Ghulam-Smith, Melissa 2021

机译：两侧到同一抗体：评估中和和非中和抗体在HIV-1的母儿传播中的作用
6. Antibody Elicited Against the gp41 N-Heptad Repeat (NHR) Coiled-Coil Can Neutralize HIV-1 with Modest Potency but Non-neutralizing Antibodies Also Bind to NHR Mimetics [O] . Josh D. Nelson, Heather Kinkead, Florence M. Brunel, -1

机译：针对gp41 N-Heptad Repeat（NHR）螺旋线圈产生的抗体可以中和HIV-1但中和力适中但非中和抗体也可与NHR模拟物结合
7. Binding of HIV-1 gp41-directed neutralizing and non-neutralizing fragment antibody binding domain (Fab) and single chain variable fragment (ScFv) antibodies to the ectodomain of gp41 in the pre-hairpin and six-helix bundle conformations. [O] . John M Louis, Annie Aniana, Katheryn Lohith, 2014

机译：HIV-1 gp41指导的中和和非中和片段抗体结合结构域（Fab）和单链可变片段（scFv）抗体与前发夹和六螺旋束构象中gp41的胞外域的结合。

Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics

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