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Simultaneous mutations at Tyr-181 and Tyr-188 in HIV-1 reverse transcriptase prevents inhibition of RNA-dependent DNA polymerase activity by the bisheteroarylpiperazine (BHAP) U-90152s

机译：HIV-1逆转录酶中Tyr-181和Tyr-188处的同时突变可防止比塞特罗芳基哌嗪（BHAP）U-90152s抑制RNA依赖性DNA聚合酶活性

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Fan Naisheng; Rank Kenneth B.; Evans David B.; Thomas Richard C.; Gary Tarpley W.; Sharma Satish K.;
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1. Simultaneous mutations at Tyr‐181 and Tyr‐188 in HIV‐1 reverse transcriptase prevents inhibition of RNA‐dependent DNA polymerase activity by the bisheteroarylpiperazine (BHAP) U‐90152s [J] . Evans David B., Fan Naisheng, Gary Tarpley W., FEBS Letters . 1995,第1a2期

机译：HIV-1逆转录酶在Tyr-181和Tyr-188处同时发生突变可阻止比塞特罗芳基哌嗪（BHAP）U-90152s抑制RNA依赖性DNA聚合酶活性
2. HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition. [J] . Wendeler Michaela, Baichoo Noel, Rausch Jason, Journal of Molecular Biology . 2009,第3期

机译：HIV-1逆转录酶可以同时在DNA聚合酶和RNase H活性位点处结合其DNA / RNA底物：这对RNase H抑制具有影响。
3. Inhibition of the DNA polymerase and RNase H activities of HIV-1 reverse transcriptase and HIV-1 replication by Brasenia schreberi (Junsai) and Petasites japonicus (Fuki) components [J] . Hisayoshi Tetsuro, Shinomura Mayu, Yokokawa Kanta, Journal of natural medicines . 2015,第3期

机译：小菜花（Junsai）和日本菜（Fatasites japonicus（Fuki））抑制HIV-1逆转录酶的DNA聚合酶和RNase H活性以及HIV-1复制
4. ESI-FTMS Assay of HIV-1 Reverse Transcriptase Activity and Possible Uncompetitive Enzyme Inhibitors [C] . Olesya Y. Chornoguz, Kevin B. Turner, Hye Young Yi-Brunozzi, ASMS Conference on Mass Spectrometry and Allied Topics . 2007

机译：HIV-1逆转录酶活性的ESI-FTMS测定和可能的缺乏竞争力酶抑制剂
5. Part I: Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase. Part II: Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV Reverse Transcriptase [D] . Neuman, Annette Welty 2013

机译：第一部分：2'-Fluoro-2'，3'-Dideoxynucleosides的合成作为丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂。第二部分：抑制HIV逆转录酶的膦酸环丁酯和氨基磷酸酯前药的合成
6. Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor [O] . Robert M. Esnouf, Jingshan Ren, Andrew L. Hopkins, 1997

机译：HIV-1逆转录酶和双（杂芳基）哌嗪（BHAP）U-90152之间的复合物结构的独特特征解释了这种非核苷抑制剂的抗性突变
7. Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor. [O] . Esnouf, RM, Ren, J, Hopkins, AL, 1997

机译：HIV-1逆转录酶和双（杂芳基）哌嗪（BHAP）U-90152之间的复合物结构的独特特征解释了这种非核苷抑制剂的耐药性突变。

Simultaneous mutations at Tyr-181 and Tyr-188 in HIV-1 reverse transcriptase prevents inhibition of RNA-dependent DNA polymerase activity by the bisheteroarylpiperazine (BHAP) U-90152s

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