首页> 外文OA文献 >Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth

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Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth

机译：通过定向衍生自原始人工人类抗体文库并针对gp41内部三聚体卷曲螺旋的单克隆Fab的CDR-H2环进行靶向多样化的亲和力成熟，可产生具有改善的HIV-1中和力和广度的Fab集合

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Gustchina Elena; Louis John M.; Frisch Christian; Ylera Francisco; Lechner Annette; Bewley Carole A.; Clore G. Marius;
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1. Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naive human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth. [J] . Gustchina E, Louis JM, Frisch C Virology . 2009,第1期

机译：通过衍生自合成的天然人抗体文库并针对gp41的内部三聚体卷曲螺旋的单克隆Fab的CDR-H2环的靶向多样化，进行亲和力成熟，可以生产出具有改善的HIV-1中和力和广度的Fab。
2. Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41 [J] . Elena Gustchina, Mi Li, John M. Louis, PLoS Pathogens . 2010,第11期

机译：针对亲和力成熟的Fabs针对gp41的内部三聚体螺旋线圈中和HIV-1的结构基础。
3. Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41 [J] . Elena Gustchina, Mi Li, John M. Louis, PLoS Pathogens . 2010,第11期

机译：针对亲和力成熟的Fabs针对gp41的内部三聚体螺旋线圈中和HIV-1的结构基础。
4. Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth [O] . Elena Gustchina, John M. Louis, Christian Frisch, -1

机译：亲和力成熟通过的单克隆Fab的CDR-H2环的有针对性的多样化由合成幼稚人抗体文库衍生的和针对gp41的的产率的一组Fab的具有改进的HIV-1中和效价和广度的内部三聚体卷曲螺旋
5. Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41 [O] . Gustchina, Elena, Li, Mi, Louis, John M., 2010

机译：针对gp41内部三聚体卷曲螺旋的亲和力成熟Fabs中和HIV-1的结构基础

Affinity maturation by targeted diversification of the CDR-H2 loop of a monoclonal Fab derived from a synthetic naïve human antibody library and directed against the internal trimeric coiled-coil of gp41 yields a set of Fabs with improved HIV-1 neutralization potency and breadth

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