Porous calcium phosphate ceramics prepared by coating polyurethane foams with calcium phosphate cements

摘要

Porous calcium phosphates have important biomedical applications such as bone defect fillers, tissue engineering scaffolds, and drug delivery systems. While a number of methods to produce the porous calcium phosphate ceramics have been reported, this study aimed to develop a new fabrication method. The new method involved the use of polyurethane foams to produce highly porous calcium phosphate cements (CPCs). By firing the porous CPCs at 1200 degrees Celsius, the polyurethane foams were burnt off and the CPCs prepared at room temperature were converted into sintered porous hydroxyapatite-based calcium phosphate ceramics. The sintered porous calcium phosphate ceramics could then be coated with a layer of the CPC at room temperature, resulting in high porosity, high pore interconnectivity, and controlled pores size.