Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(D,L-lactide)-based resins

摘要

Designed three-dimensional biodegradable poly(ethylene glycol)/poly(D,L-lactide) hydrogeludstructures were prepared for the first time by stereolithography at high resolutions. A photopolymerisableudaqueous resin comprising PDLLA-PEG-PDLLA-based macromer, visible lightudphoto-initiator, dye and inhibitor in DMSO/water was used to build the structures. Porous andudnon-porous hydrogels with well-defined architectures and good mechanical properties wereudprepared. Porous hydrogel structures with a gyroid pore network architecture showed narrowudpore size distributions, excellent pore interconnectivity and good mechanical properties. Theudstructures showed good cell seeding characteristics, and human mesenchymal stem cellsudadhered and proliferated well on these materials.