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Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PAC-P) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist

机译：人神经母细胞瘤NB-OK-1细胞膜中垂体腺苷酸环化酶激活肽（PAC-P）受体和腺苷酸环化酶激活的结构要求。发现PACAP（6-38）作为强效拮抗剂

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Robberecht Patrick; Gourlet Philippe; De Neef Philippe; Woussen Colle Marie-Claire; Vandermeers Piret Marie-Claire; Vandermeers André; Cristophe Jean;
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年度 1992
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正文语种 eng
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1. Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model [J] . Hu Essa, Hong Fang-Tsao, Aral Jennifer, Journal of Medicinal Chemistry . 2021,第6期

机译：发现选择性垂体腺苷酸环化酶1受体（PAC1R）拮抗剂肽在Maxadilan / PACAP38诱导的血流药效模型增加中效果
2. Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R). [J] . Beebe X, Darczak D, Davis-Taber RA, Bioorganic and Medicinal Chemistry Letters . 2008,第6期

机译：垂体腺苷酸环化酶激活多肽（PACAP）1型受体（PAC1-R）的酰肼拮抗剂的发现和SAR。
3. Characterization of pituitary adenylate cyclase-activating polypeptide 38 (PACAP38)-, PACAP27-, and vasoactive intestinal peptide-stimulated responses in N1E-115 neuroblastoma cells. [J] . Chik CL, Inukai T, Ogiwara T, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 1996,第3期

机译：N1E-115神经母细胞瘤细胞中垂体腺苷酸环化酶激活多肽38（PACAP38）-，PACAP27-和血管活性肠肽刺激反应的表征。
4. Biological effects of vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide receptor 1 (VPAC1) and VPAC2 on chemotaxis and its regulation of the tumor suppressor Ikaros in leukemic T cells. [D] . Van der Steen, Travis. 2012

机译：血管活性肠肽/垂体腺苷酸环化酶激活多肽受体1（VPAC1）和VPAC2的生物学效应对白血病T细胞的趋化性及其对肿瘤抑制因子Ikaros的调节。
5. Interaction of Gonadal Steroids and Gonadotropin-Releasing Hormone on Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and PACAP Receptor Expression in Cultured Rat Anterior Pituitary Cells [O] . Weiming Zheng, Constance M. Grafer, Lisa M. Halvorson -1

机译：性腺激素和促性腺激素释放激素对大鼠垂体前叶垂体中垂体腺苷酸环化酶激活多肽（PACAP）和PACAP受体表达的相互作用
6. Antagonistic properties are shifted back to agonistic properties by further N-terminal shortening of pituitary adenylate-cyclase-activating peptides in human neuroblastoma NB-OK-1 cell membranes [O] . Vandermeers, André, Vandenborre, S., Hou, Xue, 1992

机译：人类神经母细胞瘤NB-OK-1细胞膜中垂体腺苷酸环化酶激活肽的N端进一步缩短，从而使拮抗性质重新回到激动性。

Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PAC-P) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist

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