首页> 外文OA文献 >N-{4-Chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methylphenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.

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N-{4-Chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methylphenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.

机译：N- {4-氯-2-（（1,3-二氧代-1,3-二氢-2H-异吲哚-2-基）甲基苯基 -2-羟基苯甲酰胺（CPPHA）通过一个新位点充当阳性1组代谢型谷氨酸受体的变构调节剂。

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International audience

机译：国际观众

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作者
Chen Yelin; Goudet Cyril; Pin Jean-Philippe; Conn P Jeffrey;
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年度 2008
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1. N-{4-Chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl}-2-hydroxybe nzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. [J] . Chen Y, Goudet C, Pin JP, Molecular pharmacology. . 2008,第3期

机译：N- {4-氯-2-（（（1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl）methyl）phenyl）-2-hydroxybe nzamide（CPPHA）通过一个新的网站作为组1代谢型谷氨酸受体的正变构调节剂。
2. A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias tomGlu5 signaling [J] . Molecular pharmacology. . 2013,第4期

机译：新型代谢型谷氨酸受体5阳性变构调节剂作用于独特位点，并赋予刺激偏见tomGlu5信号
3. Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators [J] . Schann S., Mayer S., Franchet C., Journal of Medicinal Chemistry . 2010,第24期

机译：代谢型谷氨酸受体2沉默变构调节剂化学转化为双重代谢型谷氨酸受体2/3负/正变构调节剂
4. IDENTIFICATION OF NADPH-INDEPENDENT GSH CONJUGATES OF ACETYLENE-CONTAINING POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5 [C] . Xiaoliang Zhuo, Xiaohua Huang, Andrew Degnan, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：鉴定含乙炔谷氨酸受体亚型5的含乙炔的阳性变构调节剂的NADPH-无关的GSH缀合物
5. Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning in rodents. [D] . Fowler, Stephanie Wade. 2013

机译：代谢型谷氨酸受体5阳性变构调节剂CDPPB对啮齿类动物空间学习的影响。
6. Correction to A Novel Metabotropic Glutamate Receptor 5 Positive Allosteric Modulator Acts at a Unique Site and Confers Stimulus Bias to mGlu5 Signaling [O] . -1

机译：对一种新型代谢型谷氨酸受体5阳性变构调节剂在独特位点起作用并将刺激偏倚赋予mGlu5信号的修正
7. N-{4-Chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methylphenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. [O] . Chen Yelin, Goudet Cyril, Pin Jean-Philippe, 2008

机译：N- {4-氯-2-（（1,3-二氧代-1,3-二氢-2H-异吲哚-2-基）甲基苯基 -2-羟基苯甲酰胺（CPPHA）通过一个新位点充当阳性1组代谢型谷氨酸受体的变构调节剂。

N-{4-Chloro-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methylphenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors.

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