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Development of new lead-like dual inhibitors of the cdc2-like kinase 1 (Clk1) and dual specificity Y-phosphorylation regulated kinases 1A and 1B (Dyrk1A and Dyrk1B)

机译：开发新的类似于cdc2的激酶1（Clk1）和双重特异性Y磷酸化调节的激酶1A和1B（Dyrk1A和Dyrk1B）的铅样双重抑制剂

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Schmitt Christian;
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1. Pharmacophore and 3D-QSAR characterization of 6-arylquinazolin-4-amines as cdc2-like kinase 4 (Clk4) and dual specificity tyrosine-phosphorylation- regulated kinase 1a (Dyrk1A) inhibitors [J] . Pan Y., Wang Y., Bryant S.H. Journal of chemical information and modeling . 2013 ,第4期

机译：6-芳基喹唑啉-4-胺作为cdc2样激酶4（Clk4）和双重特异性酪氨酸磷酸化调节激酶1a（Dyrk1A）抑制剂的药理和3D-QSAR表征
2. Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) [J] . Oi Ami, Katayama Syouichi, Hatano Naoya, Biochemical and Biophysical Research Communications . 2017 ,第2期

机译：通过双重特异性酪氨酸磷酸化调节激酶1a（Dyrk1a）通过磷酸化调节细胞周期蛋白依赖性激酶样5（CDK15）的亚细胞分布
3. Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). [J] . Rosenthal AS, Tanega C, Shen M, Bioorganic and Medicinal Chemistry Letters . 2011 ,第10期

机译：强效和选择性的Cdc2样激酶（Clk）和双特异性酪氨酸磷酸化调节激酶（Dyrk）的特定同工型的小分子抑制剂。
4. MORPHOLOGICAL ANALYSIS OF COLON CANCER CELL TREATED WITH AEE788, A DUAL TYROSINE KINASE INHIBITOR AND/OR CELEXOXIB, A COX-2 SPECIFIC INHIBITOR- IMAGE PROCESSING APPROACH [C] . P Venkatesan, M Muthu Rama Krishnan, Soumen Das, International Conference on Electronic Design and Signal processing . 2012

机译：用AEE788处理的结肠癌细胞的形态学分析，双酪氨酸激酶抑制剂和/或Celexoxib，COX-2特异性抑制剂 - 图像处理方法
5. Molecular mechanisms for specific kinase inhibitors and kinase promiscuity towards inhibitors. [D] . Georghiou, George. 2014

机译：特定激酶抑制剂的分子机制和激酶与抑制剂的混杂。
6. Pharmacophore and 3D-QSAR Characterization of 6-Arylquinazolin-4-amines as Cdc2-like Kinase 4 (Clk4) and Dual Specificity Tyrosine-phosphorylation-regulated Kinase 1A (Dyrk1A) Inhibitors [O] . Yongmei Pan, Yanli Wang, *, -1

机译：6芳基喹唑啉-4-胺作为Cdc2样激酶4（Clk4）和双特异性酪氨酸磷酸化调节激酶1A（Dyrk1A）抑制剂的药理和3D-QSAR表征
7. A Novel DYRK1A (Dual Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Inhibitor for the Treatment of Alzheimer’s Disease: Effect on Tau and Amyloid Pathologies in Vitro. [O] . Coutadeur, Séverine, Benyamine, Hélène, Delalonde, Laurence, 2015

机译：新型DYRK1A（双重特异性酪氨酸磷酸化调节激酶1A）抑制剂可治疗阿尔茨海默氏病：对Tau和淀粉样蛋白病理学的影响。

Development of new lead-like dual inhibitors of the cdc2-like kinase 1 (Clk1) and dual specificity Y-phosphorylation regulated kinases 1A and 1B (Dyrk1A and Dyrk1B)

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