Identification and molecular cloning of novel antimicrobial peptides from skin secretions of Odorrana versabilis and Rana palustris

摘要

Amphibian skin secretions are an abundant source of bioactive peptides, some of which could be developed as candidate drugs. Among these natural peptides, cytolytic peptides have attracted the most attention given that they might replace conventional antibiotics and help deal with the problem of microbial resistance. This study discovered two bioactive peptides, Brevinin-1-PLr and Nigrocin-2-OV, from two species frogs, Rana palustris and Odorrana versabilis, respectively. Their antimicrobial, anticancer and hemolytic activities were also investigated.