Pulsed electric field (PEF) treatment has been shown to achieve bacterial inactivation in collagen gels whilst retaining the ability of the collagen to function as a biomaterial [1, 2]. Nisin, an antimicrobial peptide, has been used widely as a food preservative and has shown bactericidal action against a number of Gram-positive bacteria [3]. The potential of nisin to increase the efficacy of PEF disinfection of collagen gels to be used for tissue engineering applications was investigated.
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