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Simultaneous detection of drugs of abuse in waste water using gas chromatography-mass spectrometry.

机译:使用气相色谱-质谱法同时检测废水中的滥用药物。

摘要

Sewage epidemiology is increasingly becoming an alternative method of estimating drug usage and consumption patterns for a given population. With the constant emergence of new psychoactive substances such as cathinones and piperazines, versatile, reliable, specific and sensitive analytical methods are needed for their detection in complex matrices such as waste water. This thesis reports the development of an analytical method based on solid phase extraction, derivatization with pentafluoropropionic anhydride and analysis by gas chromatography-mass spectrometry for the simultaneous analysis of 29 illicit and therapeutic drugs of abuse.udAll 29 drugs could be reliably identified in spiked waste water samples using selected ion monitoring and splitless injection. Recoveries for the majority of the drugs were above 70 %. Linearity varied based on the analyte but was assessed in the range 2.0 x 10-4 to 1.4 μg/mL. Intra-assay and intermediate precision of the instrument was determined at 0.005, 0.1 and 1.0 μg/mL, with the majority of relative standard deviations less than 10 %. Limits of detection and quantification for drugs such as amphetamine and methamphetamine were better than reported values for liquid chromatography-tandem mass spectrometry, a more commonly used technique.udUntreated 72 h composite waste water samples from Cambridge, UK, were analysed using a six-point standard addition curve. Eleven drugs of abuse were detected, including amphetamine, methamphetamine, butylone and 4-fluoromethamphetamine. The latter two having been detected for the very first time in waste water. Using the validated method, the consumption of heroin, ketamine, cocaine, methamphetamine and amphetamine, in Cambridge, UK, was estimated to be 399.4 ± 90.8, 2463.5 ± 182.5, 195.5 ± 95.4, 84.3 ± 59.1 and 38.9 ± 24.8 mg/day per 1000 inhabitants.udThis is the first reported validated method for the detection of both classic drugs of abuse and new psychoactive substances in waste water using gas chromatography-mass spectrometry and derivatization with pentafluoropropionic anhydride.
机译:污水流行病学正日益成为估计给定人群药物使用和消费方式的另一种方法。随着新型精神活性物质(如卡西酮和哌嗪)的不断涌现,需要多种通用,可靠,特异和灵敏的分析方法来检测废水等复杂基质。本文报道了一种基于固相萃取,五氟丙酸酐衍生化和气相色谱-质谱联用分析同时分析29种非法和治疗性滥用药物的分析方法。 ud所有29种药物都可以可靠地鉴定为加标使用选定的离子监测和不分流进样的废水样品。大多数药物的回收率均在70%以上。线性因分析物而异,但评估范围为2.0 x 10-4至1.4μg/ mL。仪器的测定内精度和中间精度确定为0.005、0.1和1.0μg/ mL,大多数相对标准偏差小于10%。苯丙胺和甲基苯丙胺等药物的检出限和定量限均优于液相色谱-串联质谱的报告值,液相色谱-串联质谱是一种更常用的技术。 ud未经处理的来自英国剑桥的72小时复合废水样品使用六点标准加法曲线。检出了11种滥用药物,包括苯丙胺,甲基苯丙胺,丁酮和4-氟甲基苯丙胺。后两者是首次在废水中检测到。使用经验证的方法,估计英国剑桥的海洛因,氯胺酮,可卡因,甲基苯丙胺和苯丙胺的消费量为每天399.4±90.8、2463.5±182.5、195.5±95.4、84.3±59.1和38.9±24.8毫克/天1000位居民。 ud这是第一个已报道的通过气相色谱-质谱联用五氟丙酸酐衍生化检测废水中的滥用经典药物和新型精神活性物质的经过验证的方法。

著录项

  • 作者

    Mwenesongole Ellen Musili;

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  • 年度 2015
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  • 原文格式 PDF
  • 正文语种 en
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