首页> 外文OA文献 >Bioactive-Functionalized Interpenetrating Network Hydrogel (BIOF-IPN): A Novel Biomaterial Transforming the Mechanism of Bio-Repair, Bio-Adhesion and Therapeutic Capability – An In Vitro Study
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Bioactive-Functionalized Interpenetrating Network Hydrogel (BIOF-IPN): A Novel Biomaterial Transforming the Mechanism of Bio-Repair, Bio-Adhesion and Therapeutic Capability – An In Vitro Study

机译:生物活性功能互穿网络水凝胶(BIOF-IPN):一种新型生物材料,改变了生物修复,生物粘附和治疗能力的机理–一项体外研究

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摘要

The purpose of this investigation was to evaluate and report the in vitro performance of a few selected BioactiveFunctionalized Interpenetrating Network Hydrogels (BIOF-IPN); a novel biomaterial with a build-in mechanism of biorepair capacity, bio-adhesion and therapeutic capability. The study also evaluates the cytotoxicity of the newly developed material, and its ability to be used in the dental field. In this study, four bioactive-functionalized interpenetrating network hydrogels (BIOF-IPN) were prepared by dispersion of different therapeutic agents. The dentin bond strength is tested, the bio-adhesivity, modulus of elasticity and cytotoxicity of the materials were investigated, and the performance of the therapeutic-agents release profile, evaluated. The gels used in this study demonstrated excellent capacity in leading to high internal surface areas with low diffusional resistance. An increase in bond strength of the dentin treated with the BIOF-IPNs compared to the bond strength of the conventionally bonded teeth was indicated, and a significant increase in the modulus of elasticity observed. BIOF-INPs showed high adhesive force promotes binding to the negative surface of skin or dentin structure. It was found that chitosan alone increased the cell survival rate remarkably (113%) and its presence with naproxen and ibuprofen increased the cell survival rate [naproxen (93%), chitosan/naproxen (96.6%), ibuprofen (76.6%), and chitosan/ibuprofen (89.1%). The use of BIOF-IPNs has increased the time of the release of therapeutic agents, and protected the active ingredient from any type of free radical damage produced in and around the active site. Present results demonstrate the capability of the BIOF-IPNs to play an important role in the defense mechanism, and in the functional multidimensional restorative repair materials. The findings suggest that the new material would definitely find applications in functional dental composites and regenerative dentistry
机译:这项研究的目的是评估和报告几种选定的生物活性功能化互穿网络水凝胶(BIOF-IPN)的体外性能;一种具有生物修复能力,生物粘附力和治疗能力的内在机制的新型生物材料。这项研究还评估了新开发材料的细胞毒性,以及其在牙科领域的应用能力。在这项研究中,通过分散不同的治疗剂制备了四种生物活性功能化互穿网络水凝胶(BIOF-IPN)。测试牙本质结合强度,研究材料的生物粘附性,弹性模量和细胞毒性,并评估治疗剂释放曲线的性能。这项研究中使用的凝胶在产生高内表面积和低扩散阻力方面表现出出色的能力。与常规粘结的牙齿的粘结强度相比,BIOF-IPNs处理的牙本质的粘结强度得到了提高,并且观察到的弹性模量显着提高。 BIOF-INPs显示出高粘附力可促进与皮肤或牙本质结构负表面的结合。发现单独使用壳聚糖可显着提高细胞存活率(113%),与萘普生和布洛芬一起使用可提高细胞存活率[萘普生(93%),壳聚糖/萘普生(96.6%),布洛芬(76.6%)和壳聚糖/布洛芬(89.1%)。 BIOF-IPNs的使用增加了治疗剂的释放时间,并保护了活性成分免受在活性部位及其周围产生的任何类型的自由基损害。目前的结果表明,BIOF-IPN在防御机制以及功能性多维修复材料中起着重要作用。研究结果表明,这种新材料肯定会在功能性牙科复合材料和再生牙科中找到应用。

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