EFFETS DE LA PRISE DE MEDICAMENTS PSYCHOTROPES ET DE L'AGE DU CONDUCTEUR SUR LA CONDUITE, L'EVEIL ET LES FONCTIONS ATTENTIONNELLES. I. EFFET DOSE D'UN ANALGESIQUE, II. EFFET COMBINE D'UNE DOSE D'ANALGESIQUE ET D'UN HYPNOTIQUE.

摘要

Epidemiological data and the percentages of drug use do not allow to establish a causal link between a product and a possible deterioration of driving. Studies are now undertaken to understand the factors influencing changes in the level of arousal in the field of traffic safety. Our experiences fit into this framework and more particularly in that of the influence of sedatives drugs administered in therapeutic doses and under a standard therapeutic prescription. We conducted two experiments on driving simulator with different groups of healthy subjects (young, elderly), after a full night's sleep. We conducted subjective measures (questionnaires) and objective (EEG spectral analysis) measure of arousal, measures of vigilance and attention during the course of these experiments. In each experiment, psychotropic drugs studied were administered alone or in combination and compared with placebo. Our results on the dose effect of analgesic showed no effect of this drugs on driving performance, subjective arousal and vigilance in healthy young subjects. Results on the combined effect of one dose of analgesic and one hypnotic suggest no interaction between these two products in healthy elderly subjects, they do not affect the objective and subjective arousal, vigilance and attentional process. However we observe independent effects of each of these psychotropic on driving performance.