Synthesis and utilization of nitroxide free radicals and theirudprecursors as sensors and possibly biologically active molecules

摘要

Nitroxide stable free radicals have found broad appudlication as spin labels, low molecular weight udantioxidants, MRI contrast agents, co-oxidants, redudox- and pH-sensitive probes and mediators udof polymerization. The chemistry of nitroxides invoudlves many challenging aspects, including udreaction for carbon-carbon bond formation in the prudesence of amphiphilic nitroxide moieties or udthe synthesis of nitroxide containing hybrid molecuudles, for example, nitroxide incorporated udbiologically active molecules. In the frame of OTKAud104956 project we aimed to achieve new uddouble (spin and fluorescent) redox sensor moleculeuds and accomplish the synthesis of new udparamagnetically modified biomolecules, spin labelsud, complex forming agents. All these udmodifications had to be conducted with selective, budut still more or less effective reactions.