Efficient Copper-Catalyzed Trifluoromethylation of Aromatic and Heteroaromatic Iodides: The Beneficial Anchoring Effect of Borates

摘要

Efficient copperud-udcatalyzed trifluoromethylation of aromatic iodides was achieved withudTMSCFud3udin the presence ofudtrimethoxyborane. The Lewis acid was used to anchor the in situ generated trifluoromethyl anion and suppress its rapid decompudosudi-udtion. Broad applicability of the new trifluoromethylating reaction was demonstrated in the functionaliudzation of different aromaticudand heteroaroudmatic iodides.