Synthesis of Deprenyl-like nitroxide free radicals and theiruddiamagnetic derivatives

摘要

Synthesis of paramagnetically modified deprenyl and oxotremorine is reported. Starting from 5-udand 6-membered 2,5-disubstituted nitrones (1, 6) or 4-phenyl-2,5,5-trimethyl-1H-pyrroline 1-oxide (11) deprenyl or oxotremorine like nitroxides were synthesized via Grignard reactions. The corresponding pre-nitroxides with propargylamine structure were achieved by reduction ofudnitroxides followed by methylation.