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Regeneration of New Neurons is Preserved in Aged Vomeronasal Epithelia

机译:新的神经元的再生保留在老的犁鼻鼻上皮中

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摘要

During normal and diseased aging, it is thought the capacity for tissue regeneration and repair in neuronal tissues diminishes. In the peripheral olfactory system, stem cell reservoirs permit regeneration of olfactory and vomeronasal sensory neurons, a unique capacity among neurons. Following injury, a large number of new neurons can be regenerated in a young animal. However, it is unknown whether this capacity for renewal exists in aged proliferative populations. Here, we report that neuronal replacement-associated proliferation continues in the vomeronasal organ of aged (18-24 months) mice. In addition, the potential for the aged stem cell to yield a mature neuron persisted at the same rate as that observed in young animals. Furthermore, the robust regenerative capacity to respond to both acute and sustained injury following olfactory bulbectomy remains intact even in very old animals. Hence, the neuronal epithelium lining the vomeronasal organ is unique in that it contains stem cells capable of generating functional neurons throughout life and in the aged animal in particular. This persistent regenerative capacity provides hope for neuronal replacement therapies in the aged nervous system.
机译:在正常和患病的衰老期间,认为神经元组织中组织再生和修复的能力降低。在周围的嗅觉系统中,干细胞储库允许嗅觉和犁鼻感觉神经元的再生,这是神经元中的独特功能。受伤后,可以在幼小动物中再生大量新的神经元。但是,这种增生能力是否存在于老年增生人群中尚不清楚。在这里,我们报告说,在年龄较大的小鼠(18-24个月)的犁鼻鼻器官中,神经元置换相关的增殖仍在继续。此外,衰老的干细胞产生成熟神经元的潜力以与年轻动物相同的速率持续存在。此外,即使在非常老的动物中,嗅球切除术后对急性和持续伤害的反应也具有很强的再生能力。因此,位于犁鼻器器官内的神经元上皮是独特的,因为它包含能够在整个生命中,尤其是在老年动物中产生功能性神经元的干细胞。这种持续的再生能力为老年神经系统中的神经元替代疗法提供了希望。

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