Gold for Ubiquitin in Vancouver: FIRST CONFERENCE ON PROTEOMICS OF PROTEIN DEGRADATION AND UBIQUITIN PATHWAYS HELD JUNE 6–8, 2010 IN VANCOUVER, UNIVERSITY OF BRITISH COLUMBIA, ORGANIZED BY LAN HUANG, THIBAULT MAYOR, AND PEIPEI PING*

摘要

The rise of proteomics has had tremendous influence on analysis and understanding of the role of post-translational modifications in biological processes. The covalent attachment of small proteins like ubiquitin, SUMO,1 or other ubiquitin-like proteins (Ubls) is one class of post-translational modifications where proteomics has had notable impact. Various proteomics approaches, but in particular mass spectrometry-based analyses, have influenced the field and enabled significant advances over the past few years. The first meeting dedicated to proteomics of protein degradation and ubiquitin pathways showcased these advances and allowed a glimpse at future contributions of proteomics to this field. With its many attractive drug targets, the ubiquitin and proteasome system, as well as other proteolysis pathways, could offer new therapies for various human diseases including cancer and neurodegenerative disorders.