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Optical imaging of reporter gene expression using a positron-emission-tomography probe

机译:使用正电子发射断层扫描探针对报告基因表达的光学成像

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摘要

Reporter gene∕reporter probe technology is one of the most important techniques in molecular imaging. Lately, many reporter gene∕reporter probe systems have been coupled to different imaging modalities such as positron emission tomography (PET) and optical imaging (OI). It has been recently found that OI techniques could be used to monitor radioactive tracers in vitro and in living subjects. In this study, we further demonstrate that a reporter gene∕nuclear reporter probe system [herpes simplex virus type-1 thymidine kinase (HSV1-tk) and 9-(4-18F-fluoro-3-[hydroxymethyl] butyl) guanine ([18F]FHBG)] could be successfully imaged by OI in vitro and in vivo. OI with radioactive reporter probes will facilitate and broaden the applications of reporter gene∕reporter probe techniques in medical research.
机译:记者基因记者探针技术是分子成像领域最重要的技术之一。近来,许多报告基因/报告探针系统已与不同的成像方式耦合,例如正电子发射断层扫描(PET)和光学成像(OI)。最近发现,OI技术可用于在体外和活体受试者中监测放射性示踪剂。在这项研究中,我们进一步证明了一种报告基因-核报告基因探针系统[单纯疱疹病毒1型胸苷激酶(HSV1-tk)和9-(4-18F-氟-3- [羟甲基]丁基)鸟嘌呤([ 18F] FHBG)]可以通过OI在体内和体外成功成像。带有放射性报告探针的OI将促进并扩大报告基因∕报告探针技术在医学研究中的应用。

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