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Electrospun Nanostructured Fibers of Collagen-Biomimetic Apatite on Titanium Alloy

机译:钛合金上仿生磷灰石电纺纳米结构纤维

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摘要

Titanium and its alloys are currently the mainly used materials to manufacture orthopaedic implants due to their excellent mechanical properties and corrosion resistance. Although these materials are bioinert, the improvement of biological properties (e.g., bone implant contact) can be obtained by the application of a material that mimics the bone extracellular matrix. To this aim, this work describes a new method to produce nanostructured collagen-apatite composites on titanium alloy substrate, by combining electrospinning and biomimetic mineralization. The characterization results showed that the obtained mineralized scaffolds have morphological, structural, and chemical compositional features similar to natural bone extracellular matrix. Finally, the topographic distribution of the chemical composition in the mineralized matrix evaluated by Fourier Transform Infrared microspectroscopy demonstrated that the apatite nanocrystals cover the collagen fibers assembled by the electrospinning.
机译:钛及其合金由于其优异的机械性能和耐腐蚀性,目前是制造骨科植入物的主要材料。尽管这些材料是生物惰性的,但是可以通过应用模仿骨细胞外基质的材料来获得生物学特性(例如,骨植入物接触)的改善。为此,这项工作描述了一种通过结合静电纺丝和仿生矿化在钛合金基底上生产纳米结构胶原-磷灰石复合材料的新方法。表征结果表明,所获得的矿化支架具有与天然骨细胞外基质相似的形态,结构和化学组成特征。最后,通过傅立叶变换红外显微术评估的矿化基质中化学成分的形貌分布表明,磷灰石纳米晶体覆盖了通过电纺组装的胶原纤维。

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