Identification of sumoylation targets, combined with inactivation of SMT3, reveals the impact of sumoylation upon growth, morphology, and stress resistance in the pathogen Candida albicans

摘要

Through proteomic identification of sumoylated proteins, combined with detailed molecular and cellular analyses of conditional and null smt3/smt3 mutants, the small ubiquitin-like modifier, SUMO, is shown to play key roles in cellular growth and stress adaptation of the major fungal pathogen Candida albicans.