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Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target

机译：Autotaxin：在黑色素瘤细胞生物学中的作用以及作为药理学靶标

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Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA1-LPA6) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed.

机译：Autotaxin（ATX）是从正常细胞和癌细胞释放的细胞外溶血磷脂酶D（lysoPLD）。在各种生物流体中检测到ATX的活性。溶血磷脂酸（LPA）是ATX的主要产品。通过特定的G蛋白偶联受体（LPA1-LPA6）起作用的LPA影响免疫反应，正常发育以及恶性肿瘤的形成和发展。在这篇综述中，讨论了自毒素对黑素瘤细胞生物学的影响和潜在的治疗方法。

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Jankowski, Maciej;
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年度 2011
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正文语种 {"code":"en","name":"English","id":9}
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专利

1. Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target [J] . MaciejJankowski Enzyme Research . 2011,第1期

机译：Autotaxin：其在黑色素瘤细胞生物学中的作用以及作为药理学靶标
2. CYCLIN-DEPENDENT KINASES AS DRUG TARGETS FOR CELL GROWTH AND PROLIFERATION DISORDERS. A ROLE FOR SYSTEMS BIOLOGY APPROACH IN DRUG DEVELOPMENT. PART II - CDKs AS DRUG TARGETS IN HYPERTROPHIC CELL GROWTH. MODELLING OF DRUGS TARGETING CDKs [J] . Michael A. Idowu Biotechnology & Biotechnological Equipment . 2012,第1期

机译：依赖细胞周期的激酶作为细胞生长和增殖障碍的药物靶标。药物开发中系统生物学方法的作用。第二部分-CDKs作为肥大细胞生长的药物靶标。药物靶向CDK的建模
3. Cyclin-Dependent Kinases as Drug Targets for Cell Growth and Proliferation Disorders. A Role for Systems Biology Approach in Drug Development. Part II?￠????CDKs as Drug Targets in Hypertrophic Cell Growth. Modelling of Drugs Targeting CDKs [J] . Michael A. Idowu Biotechnology & Biotechnological Equipment . 2012,第1期

机译：细胞周期蛋白依赖性激酶作为细胞生长和增殖障碍的药物靶标。系统生物学方法在药物开发中的作用。第二部分CDKs作为肥大细胞生长中的药物靶标。靶向CDK的药物建模
4. A Machine Learning Approach to Pharmacological Profiling of the Quinone Scaffold in the NCI Database: A Compound Class Enriched in Those Effective Against Melanoma and Leukemia Cell Lines [C] . ML Ujwaf Patrick Hoffman, Kenneth A. Marx IEEE International Symposium on Bioinformatics and Bioengineering . 2007

机译：NCI数据库中醌支架的药理仿形机器学习方法：富含黑素瘤和白血病细胞系的复合类
5. The role of Sprouty-dependent inhibition of the Ras /ERK pathway in melanoma cells: A systems biology approach. [D] . Tsavachidou, Dimitra. 2005

机译：黑素瘤细胞中Ras / ERK途径的Sprouty依赖性抑制的作用：一种系统生物学方法。
6. Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target [O] . Maciej Jankowski 2011

机译：Autotaxin：在黑色素瘤细胞生物学中的作用以及作为药理学靶标
7. A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC [O] . Lai, Johnathan C., Tan, Wenzhi, Benimetskaya, Luba, 2006

机译：黑色素瘤细胞中G3139的药理靶点可能是线粒体VDAC

Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target

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