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Electrophysiological and mechanical effects of calcitonin gene-related peptide on guinea-pig atria.

机译:降钙素基因相关肽对豚鼠心房的电生理和机械作用。

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摘要

1. The effects of calcitonin gene-related peptide (CGRP) on mechanical and electrophysiological responses were studied in the guinea-pig atrial muscle preparations and in single cells. 2. CGRP (greater than 10(-9) M) enhanced the twitch contraction in a concentration-dependent manner in electrically driven left atria and increased heart rate in spontaneously beating right atria. The positive inotropic and chronotropic effects of CGRP were not inhibited by propranolol but were attenuated by reduction of the calcium concentration in the bathing medium. 3. In single left atrial cells, CGRP slightly hyperpolarized the resting potential but did not affect the other action potential parameters significantly. 4. Under whole-cell voltage-clamp conditions, CGRP increased the calcium inward current. The peptide also increased the steady inward current elicited by hyperpolarization and the late outward current by depolarization. 5. These results suggest that CGRP may produce the positive inotropic and presumably chronotropic effects by increasing calcium inward current. CGRP also increases the potassium permeability. Such effects on ionic currents may not produce any apparent change in the action potential conformation, due to their opposite directional actions and relatively weak potencies.
机译:1.在豚鼠心房肌制剂和单细胞中研究了降钙素基因相关肽(CGRP)对机械和电生理反应的影响。 2. CGRP(大于10(-9)M)以电驱动的左心房以浓度依赖的方式增强了抽搐收缩,并在自发跳动的右心房中增加了心率。普萘洛尔不会抑制CGRP的正性变力和变时性作用,但通过降低沐浴介质中的钙浓度可以减弱CGRP的正性和变时性作用。 3.在单个左心房细胞中,CGRP稍微使静息电位超极化,但并未显着影响其他动作电位参数。 4.在全细胞电压钳制条件下,CGRP增加了钙内向电流。该肽还增加了由超极化引起的稳定的内向电流和由去极化引起的晚期的外向电流。 5.这些结果表明,CGRP可通过增加钙内向电流产生正性变力作用,并可能产生变时性作用。 CGRP还增加了钾的渗透性。由于其相反的方向作用和相对弱的电势,因此对离子电流的这种作用可能不会在作用电位构象上产生任何明显的变化。

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