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ClC-7 is a slowly voltage-gated 2Cl−/1H+-exchanger and requires Ostm1 for transport activity

机译：ClC-7是一种缓慢电压门控2Cl− / 1H +交换器，需要Ostm1进行转运

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摘要

ClC-7/Ostm1 is a disease-relevant lysosomal ion transporter. This study characterizes the functional properties of ClC-7/Ostm1 and disease-relevant mutants for the first time and extends the concept of voltage gating to ion exchangers.

机译：ClC-7 / Ostm1是与疾病相关的溶酶体离子转运蛋白。这项研究首次表征了ClC-7 / Ostm1和与疾病相关的突变体的功能特性，并将电压门控的概念扩展到离子交换剂。

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作者
Leisle, Lilia; Ludwig, Carmen F; Wagner, Florian A; Jentsch, Thomas J; Stauber, Tobias;
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年度 2011
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正文语种 en
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专利

1. Common Gating of Both CLC Transporter Subunits Underlies Voltage-dependent Activation of the 2Cl?/1H+ Exchanger ClC-7/Ostm1 [J] . Carmen Ludwig, Florian Ullrich, Lilia Leisle, The Journal of biological chemistry . 2013,第40期

机译：CLC传输亚基的常见门控下降2CLΔ/ 1H +交换器CLC-7 / OSTM1的电压依赖性激活
2. Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions [J] . Stefanie Weinert, Sabrina Jabs, Svea Hohensee, EMBO reports . 2014,第7期

机译：转运活动和ClC-7 / Ostm1复合物的存在导致了不同的细胞功能
3. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin [J] . Archan Ganguly, Xuemei Han, Utpal Das, Journal of cell biology . 2017,第7期

机译：Hsc70伴侣活性是突触蛋白胞质缓慢轴突运输所必需的
4. A role of Na~+-K~+-2Cl~- cation-chloride cotransporters on spinal pain transmission [C] . Fumi Yanagidate, He Yanbing, Chen Gui Hua, European Meeting on Glial Cells in Health and Disease . 2009

机译：Na〜+ -K〜+ -2CL〜阳离子 - 氯化物Cotoransporters对脊柱疼痛传播的作用
5. If you want to be slow you have to be fast: Control of slow population activities by fast-spiking interneurons via network multistability [D] . Ho, Ernest Chun Yue 2011

机译：如果您想变慢，就必须变快：通过网络多重稳定性，通过快速增加中间神经元来控制慢速种群活动
6. ClC-7 is a slowly voltage-gated 2Cl−/1H+-exchanger and requires Ostm1 for transport activity [O] . Lilia Leisle, Carmen F Ludwig, Florian A Wagner, 2011

机译：ClC-7是一种缓慢电压门控2Cl− / 1H +交换器需要Ostm1进行转运
7. Common Gating of Both CLC Transporter Subunits Underlies Voltage-dependent Activation of the 2Cl−/1H+ Exchanger ClC-7/Ostm1 [O] . Carmen F. Ludwig, Florian Ullrich, Lilia Leisle, 2013

机译：CLC传输亚基的常见门控下降2CL- / 1H +交换器CLC-7 / OSTM1的电压依赖性激活
8. Synthesis, Structural Characterization, and Reactivity of (Me3CCH2)2GaAs(SiMe3)2Ga(CH2CMe3)2Cl, ((Me3CCH2)2GaAs(SiMe3)2)2, and (Me3CCH2)2Ga(Cl)As(SiMe3)3. [R] . Wells, R. L., McPhail, A. T., Pasterczyk, J. W., 1991

机译：（me3CCH2）2Gaas（sime3）2Ga（CH2Cme3）2Cl，（（me3CCH2）2Gaas（sime3）2）2和（me3CCH2）2Ga（Cl）as（sime3）3的合成，结构表征和反应性。

ClC-7 is a slowly voltage-gated 2Cl−/1H+-exchanger and requires Ostm1 for transport activity

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