首页> 外文OA文献 >Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytes.
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Anti-L3T4 antibody inhibits the lysis of H-2 class II antigen-negative target cells by L3T4+ cytotoxic T lymphocytes.

机译:抗L3T4抗体通过L3T4 +细胞毒性T淋巴细胞抑制H-2 II类抗原阴性靶细胞的裂解。

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摘要

Anti-L3T4 monoclonal antibodies inhibit the cytotoxic activity of L3T4+ cytotoxic T lymphocytes specific for H-2 class I antigens. The P815 target cells used to detect this population of murine cytolytic cells are shown by immunofluorescence, radioimmunoprecipitation, and RNA blot analysis not to express H-2 class II protein or mRNA. Contrary to previously proposed models regarding its function, we conclude that the L3T4 molecule is involved at some stage of the lytic interaction between the class I-specific L3T4+ effector cell and its target cell by a mechanism for which there is not an obligatory requirement for H-2 class II antigen expression by the target cell. L3T4 may be an early component of the system that transduces the activation signal from the T-cell receptor complex to the cytoplasm, a cell-surface receptor for a yet undefined natural ligand that delivers a negative signal to the killer T cell, or it may modulate the avidity of the antigen-specific T-cell receptor through a direct physical association with it.
机译:抗L3T4单克隆抗体抑制对H-2 I类抗原具有特异性的L3T4 +细胞毒性T淋巴细胞的细胞毒活性。通过免疫荧光,放射免疫沉淀和RNA印迹分析显示,用于检测鼠类溶细胞细胞的P815靶细胞不表达H-2 II类蛋白质或mRNA。与先前提出的有关其功能的模型相反,我们得出结论,L3T4分子是通过一种对H没有强制要求的机制参与了I类L3T4 +效应细胞及其靶细胞之间的溶解相互作用的某个阶段。 -2 II类抗原被靶细胞表达。 L3T4可能是系统的早期组成部分,其将激活信号从T细胞受体复合物转导到细胞质,一种尚未确定的天然配体的细胞表面受体,其向杀伤性T细胞传递负信号,或者通过与抗原特异性T细胞受体的直接物理关联来调节其特异性。

著录项

  • 作者

    Macphail, S; Stutman, O;

  • 作者单位
  • 年度 1988
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  • 原文格式 PDF
  • 正文语种 en
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