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Idiotypic regulation of the immune system. Common idiotypic specificities between idiotypes and antibodies raised against anti- idiotypic antibodies in rabbits

机译:免疫系统的独特型调节。兔的独特型和抗体之间的共同独特型特异性

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摘要

Anti-idiotypic antibodies (Ab2) were raised in allotype-matched rabbits against anti-carbohydrate or anti-tobacco mosaic virus antibodies (Ab1). Several Ab2 were purified and injected into a third series of rabbits III which synthesized antiantiidiotypic antibodies (Ab3). Antigen was then given for the first time in those rabbits who had synthesized Ab3. The specific antibody synthesized in rabbits III was called Ab1'. Anti-idiotypic antibodies were raised against purified Ab3 antibodies (Ab4). In most cases, Ab1' antibodies are sharing idiotypic specificities with Ab1. Ab3 did not react with antigen but shared idiotopes with Ab1 and Ab1' because Ab4 antibodies, which are anti- idiotypes to Ab3 do recognize specifically Ab1 and Ab1' antibodies belonging to the same chain of immunization. It seems therefore that Ab3 looks idiotypically like Ab1 and Ab4 displays the same behaviour as Ab2. A general view of the functioning of the immune system is presented.
机译:在同种异型匹配的兔中产生了抗独特型抗体(Ab2),以抗碳水化合物或抗烟草花叶病毒抗体(Ab1)。纯化了几种Ab2,并将其注射到合成抗抗独特型抗体(Ab3)的第三批兔子III中。然后首次在合成Ab3的兔子中给予抗原。在兔III中合成的特异性抗体称为Ab1'。产生了针对纯化的Ab3抗体(Ab4)的抗独特型抗体。在大多数情况下,Ab1'抗体与Ab1具有独特的特异性。 Ab3不与抗原反应,但与Ab1和Ab1'共享同分型,因为Ab4的抗独特型Ab4抗体确实能特异性识别属于同一免疫链的Ab1和Ab1'抗体。因此,似乎Ab3看起来很像Ab1,而Ab4表现出与Ab2相同的行为。呈现了免疫系统功能的一般视图。

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  • 年度 1979
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