首页> 外文OA文献 >IMMUNE RESPONSES AGAINST NATIVE AND CHEMICALLY MODIFIED ALBUMINS IN MICE : I. ANALYSIS OF NON-THYMUS-PROCESSED (B) AND THYMUS-PROCESSED (T) CELL RESPONSES AGAINST METHYLATED BOVINE SERUM ALBUMIN
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IMMUNE RESPONSES AGAINST NATIVE AND CHEMICALLY MODIFIED ALBUMINS IN MICE : I. ANALYSIS OF NON-THYMUS-PROCESSED (B) AND THYMUS-PROCESSED (T) CELL RESPONSES AGAINST METHYLATED BOVINE SERUM ALBUMIN

机译:对小鼠天然和化学修饰的白蛋白的免疫反应:I.对甲基化牛血清白蛋白的非胸腺加工(B)和胸腺加工(T)细胞反应的分析

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摘要

Immune cells induced by bovine serum albumin (BSA) and its methylated derivative (MBSA) have been compared in a cooperative cell transfer system for their content of BSA-specific antibody-forming cell precursors (AFCP, B) and BSA-specific helper (T) cells. When MBSA immune cells were transferred together with hapten-primed cells into recipient mice which were stimulated by a hapten-BSA conjugate, their cooperative secondary anti-hapten response was as good as in case of transferred BSA immune cells. Their secondary anti-BSA response, however, was markedly reduced (reduction factor > 30). Hapten-MBSA conjugates had the same capacity to react with BSA-specific helper cells in the cooperative secondary anti-hapten response as hapten-BSA conjugates but had a reduced ability to react with BSA-specific AFCP cells. In spite of the pronounced reduction of the B cell response, MBSA had the same threshold dose as BSA for activating BSA-specific T cells. These data suggest that B and T cells recognize different epitopes on the BSA molecule, only those recognized by B cells being affected by the methylation procedure.
机译:牛血清白蛋白(BSA)及其甲基化衍生物(MBSA)诱导的免疫细胞已在协作细胞转移系统中进行了比较,它们的BSA特异性抗体形成细胞前体(AFCP,B)和BSA特异性辅助细胞(T ) 细胞。当MBSA免疫细胞与半抗原引发的细胞一起转移到受半抗原-BSA偶联物刺激的受体小鼠中时,它们的协同次级抗半抗原应答与转移的BSA免疫细胞一样好。然而,它们的继发性抗-BSA反应显着降低(降低因子> 30)。 Hapten-MBSA共轭物与半抗原-BSA共轭物具有在协同性次级抗半抗原应答中与BSA特异性辅助细胞反应的能力,但与BSA特异性AFCP细胞反应的能力却有所降低。尽管B细胞反应明显降低,但MBSA具有与BSA相同的阈值剂量,用于激活BSA特异性T细胞。这些数据表明,B细胞和T细胞识别BSA分子上的不同表位,只有被B细胞识别的那些才受到甲基化程序的影响。

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  • 年度 1972
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