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Ligand Specificity of a High Affinity Cytokinin-binding Protein 1

机译:高亲和力细胞分裂素结合蛋白1的配体特异性。

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摘要

A soluble cytokinin-binding protein from wheat germ that has a high affinity for a range of purine cytokinins also interacts with a variety of nonpurine compounds that can affect cytokinin-modified processes in animal or plant cells or which bind to proteins known to interact with certain cytokinins. A variety of structurally disparate compounds which inhibit chloroplast photosystem II activity (including phenylurea, carbanilate, and alkylamino-2-chloro-sym-triazine compounds) displace kinetin from the protein in an apparently competitive fashion. However, various energy transfer inhibitors (including organotin compounds and N,N′-dicy-clohexylcarbodiimide) also inhibit kinetin binding to the protein. N6,2-0′-Dibutyryl-3′,5′-cyclic AMP and 1-methyl-3-isobutylxanthine (the effects of which on fibroblast morphology and motility can be mimicked by cytokinins) are inhibitors of kinetin binding to the protein. A variety of compounds that can have antimitotic effects (including 1-methyl-3-isobutylxanthine and certain alkylated cyclic nucleotide, carbanilate, and tryptamine compounds) displace kinetin from the protein. However, a variety of indole derivatives also displace kinetin from the cytokinin-binding protein, which in a qualitative sense has a broad ligand specificity.
机译:对一系列嘌呤细胞分裂素具有高亲和力的小麦胚芽可溶性细胞分裂素结合蛋白还与多种非嘌呤化合物相互作用,这些非嘌呤化合物可影响动植物细胞中细胞分裂素修饰的过程,或与已知与某些细胞相互作用的蛋白质结合细胞分裂素。抑制叶绿体光系统II活性的各种结构上不同的化合物(包括苯脲,氨基甲酸酯和烷基氨基-2-氯-符号三嗪化合物)以明显竞争的方式从蛋白质上取代了激动素。但是,各种能量转移抑制剂(包括有机锡化合物和N,N'-dic-clohexylcarbodiimide)也抑制激动素与蛋白质的结合。 N6,2-0'-Dibutyryl-3',5'-环AMP和1-甲基-3-异丁基黄嘌呤(可通过细胞分裂素模拟其对成纤维细胞形态和运动的影响)是激动素与蛋白质结合的抑制剂。各种可能具有抗有丝分裂作用的化合物(包括1-甲基-3-异丁基黄嘌呤和某些烷基化的环状核苷酸,氨基甲酸酯和色胺等化合物)可将激动素从蛋白质中置换出来。然而,多种吲哚衍生物也从细胞分裂素结合蛋白上取代了激动素,从定性意义上说,其具有广泛的配体特异性。

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