As part of a multiyear birth-cohort study examining the roles of pre- and postnatal environmental exposures on developmental deficits and asthma among children, we measured personal exposures to polycyclic aromatic hydrocarbons (PAHs) among 348 pregnant women in northern Manhattan and the South Bronx, New York. Nonsmoking African-American or Dominican women were identified and recruited into the study. During the third trimester of pregnancy, each subject wore a personal air monitor for 48 hr to determine exposure levels to nine PAH compounds. In this study, we examined levels of exposures to PAHs and tested for associations with potential predictor variables collected from questionnaires addressing socioeconomic factors and day-to-day activities during pregnancy as well as activities and environmental exposures during the 48-hr monitoring period. Reliable personal monitoring data for women who did not smoke during the monitoring period were available for 344 of 348 subjects. Mean PAH concentrations ranged from 0.06 ng/m3 for dibenz[a,h]anthracene to 4.1 ng/m3 for pyrene; mean benzo[a]pyrene concentration was 0.50 ng/m3. As found in previous studies, concentrations of most PAHs were higher in winter than in summer. Multiple linear regression analysis revealed associations between personal PAH exposures and several questionnaire variables, including time spent outdoors, residential heating, and indoor burning of incense. This is the largest study to date characterizing personal exposures to PAHs, a ubiquitous class of carcinogenic air contaminants in urban environments, and is unique in its focus on pregnant minority women.
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机译:作为一项为期多年的研究队列研究的一部分,该研究考察了出生前和产后环境暴露对儿童发育缺陷和哮喘的作用,我们测量了曼哈顿北部和南布朗克斯地区348名孕妇的个人暴露于多环芳烃的暴露水平,纽约。确定了非吸烟的非裔美国人或多米尼加妇女,并将其招募到研究中。在妊娠的三个月中,每个受试者都佩戴个人空气监测仪48小时,以确定9种PAH化合物的暴露水平。在这项研究中,我们检查了PAHs的暴露水平,并测试了与从问卷中收集的潜在预测变量的关联性,这些变量针对的是怀孕期间的社会经济因素和日常活动,以及48小时监测期间的活动和环境暴露。对于348名受试者中的344名,在监测期间没有吸烟的女性提供了可靠的个人监测数据。 PAH的平均浓度范围从苯并[a,h]蒽的0.06 ng / m3到pyr的4.1 ng / m3;苯并[a] py的平均浓度为0.50 ng / m3。如先前的研究发现,冬季大多数PAHs的浓度要高于夏季。多元线性回归分析揭示了个人PAH暴露与几个问卷变量之间的关联,包括户外花费的时间,住宅取暖和室内熏香。这是迄今为止迄今为止最大的一项研究,其特征是个人暴露于城市环境中普遍存在的致癌性空气污染物一类多环芳烃,并且其针对怀孕的少数民族妇女的独特性。
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