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Attraction within the membrane: Forces behind transmembrane protein folding and supramolecular complex assembly

机译:膜内吸引:跨膜蛋白折叠和超分子复合物组装背后的作用力

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摘要

Biological membranes are fascinating two-dimensional microenvironments that exhibit unique solvent behaviours due to their varying lipid composition. Although many important bioenergetic and signalling events involve the transient or permanent assembly of membrane protein complexes, the characterization of the thermodynamic and kinetic properties behind this assembly is just beginning. In particular, the molecular forces that govern protein association within these structures remain poorly understood. An understanding of the docking of transmembrane proteins to supramolecular complexes, which will make possible the development of predictive computational tools, will require detailed knowledge of interaction forces at the atomistic or residue level. Here, I review current data on supramolecular complexes in membrane environments and make a tentative comparison between assembly processes in membranes and those driven by the hydrophobic effect in water. This comparison suggests that, in addition to being controlled by specific characteristics of the lipid molecules themselves, molecular assembly in the membrane milieu also depends more generally on the entropy of the lipid fraction.
机译:生物膜具有迷人的二维微环境,由于它们的脂质组成不同,它们表现出独特的溶剂行为。尽管许多重要的生物能和信号传递事件涉及膜蛋白复合物的瞬时或永久组装,但表征该组装背后的热力学和动力学性质才刚刚开始。特别是,控制这些结构内蛋白质缔合的分子力仍然知之甚少。对跨膜蛋白与超分子复合物对接的理解,这将使预测计算工具的发展成为可能,这需要在原子或残基水平上对相互作用力的详细了解。在这里,我回顾了有关膜环境中超分子复合物的最新数据,并对膜中的组装过程与水中的疏水作用驱动的过程进行了初步比较。该比较表明,除了受脂质分子本身的特定特征控制之外,膜环境中的分子组装还更普遍地取决于脂质级分的熵。

著录项

  • 作者

    Helms, Volkhard;

  • 作者单位
  • 年度 2002
  • 总页数
  • 原文格式 PDF
  • 正文语种 en
  • 中图分类
  • 入库时间 2022-08-31 15:27:33

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