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High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

机译：高通量化学筛选可识别细胞昼夜节律的新型有效调节剂，并揭示CKIα作为时钟调节激酶。

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A novel compound “longdaysin” was found to dramatically slow down the speed of the circadian clock through simultaneous inhibition of protein kinases CKIδ, CKIα, and ERK2.

机译：发现一种新型化合物“ longdaysin”通过同时抑制蛋白激酶CKIδ，CKIα和ERK2来显着降低昼夜节律的速度。

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Hirota, Tsuyoshi; Lee, Jae Wook; Lewis, Warren G.; Zhang, Eric E.; Breton, Ghislain; Liu, Xianzhong; Garcia, Michael; Peters, Eric C.; Etchegaray, Jean-Pierre; Traver, David; Schultz, Peter G.; Kay, Steve A.;
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年度 2010
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1. High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase [J] . Tsuyoshi Hirota, Jae Wook Lee, Warren G. Lewis, PLoS Biology . 2010,第12期

机译：高通量化学筛选可识别细胞昼夜节律的新型有效调节剂，并揭示CKIα作为时钟调节激酶。
2. The Use of Chemical Compounds to Identify the Regulatory Mechanisms of Vertebrate Circadian Clocks [J] . Okamoto-Uchida Yoshimi, Nishimura Akari, Izawa Junko, Current drug targets-The International journal for timely in-depth reviews on drug targets . 2020,第5期

机译：使用化合物来确定脊椎动物昼夜钟的调节机制
3. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth [J] . Tsuyoshi Oshima, Yoshimi Niwa, Keiko Kuwata, Science Advances . 2019,第1期

机译：基于细胞的筛选确定了一种新的有效且高度选择性的CK2抑制剂，可调节昼夜节律和癌细胞生长
4. HIGH-THROUGHPUT SCREENING OF CHEMICAL LIBRARIES FOR MODULATORS OF MESENCHYMAL STEM CELL CHONDROGENESIS [C] . Alice H. Huang, Nuzhat A. Motlekar, Ashley Stein, ASME summer bioengineering conference;SBC2008 . 2009

机译：间充质干细胞软骨形成调节剂化学文库的高通量筛选
5. Circadian rhythms in Synechococcus elongatus PCC 7942: Insights into the regulatory mechanisms of the cyanobacterial clock system. [D] . Mackey, Shannon Rose. 2006

机译：延伸聚球菌PCC 7942中的昼夜节律：洞察蓝细菌时钟系统的调节机制。
6. High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase [O] . Tsuyoshi Hirota, Jae Wook Lee, Warren G. Lewis, 2010

机译：高通量化学筛选可识别细胞昼夜节律的新型有效调节剂并揭示CKIα作为时钟调节激酶。
7. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. [O] . Tsuyoshi Hirota, Jae Wook Lee, Warren G Lewis, 2010

机译：高通量化学筛选鉴定了一种新的有效的细胞昼夜节律调节剂，并将CKIα显示为时钟调节激酶。

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

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