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Structural features of the uniporter/symporter/antiporter superfamily.

机译:单向子/同向子/反向子超家族的结构特征。

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摘要

The uniporter/symporter/antiporter superfamily is an evolutionarily related group of solute transporters. For the entire superfamily, we have used a new predictive program to identify the transmembrane domains. These transmembrane domains were then analyzed with regard to their overall hydrophobicity and amphipathicity. In addition, the lengths of the hydrophilic loops connecting the transmembrane domains were calculated. These data, together with structural information in the literature, were collectively used to produce a general model for the three-dimensional arrangement of the transmembrane domains.
机译:单向转运蛋白/同向转运蛋白/反转运蛋白超家族是溶质转运蛋白的进化相关群。对于整个超家族,我们使用了新的预测程序来识别跨膜结构域。然后对这些跨膜结构域的整体疏水性和两亲性进行分析。另外,计算了连接跨膜结构域的亲水环的长度。这些数据,连同文献中的结构信息一起,被用于产生跨膜结构域的三维排列的通用模型。

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