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Angiotensin converting enzyme in bronchoalveolar lavage fluid in pulmonary sarcoidosis.

机译:肺结节病支气管肺泡灌洗液中的血管紧张素转化酶。

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摘要

Alveolar angiotensin converting enzyme (ACE) and serum ACE were measured simultaneously in 16 patients with histologically confirmed sarcoidosis and in 16 control subjects. Although alveolar ACE was abnormally elevated in all 15 cases of active sarcoidosis, serum ACE was not. No correlations were found between radiographic staging of pulmonary sarcoidosis and the levels of these enzymes. There was a clear correlation, however, between the levels of alveolar ACE and counts made on bronchoalveolar lavage fluid. This correlation was closer than that existing between serum ACE and bronchoalveolar lavaged lymphocytes. It is suggested that alveolar ACE is an additional biological marker of pulmonary sarcoidosis which is possibly more sensitive than serum ACE.
机译:在16例经组织学证实为结节病的患者和16例对照受试者中,同时测量了肺泡血管紧张素转化酶(ACE)和血清ACE。尽管所有15例活动性结节病患者的肺泡ACE均异常升高,但血清ACE并未升高。肺结节病的影像学分期与这些酶的水平之间没有相关性。但是,肺泡ACE水平与支气管肺泡灌洗液计数之间存在明显的相关性。该相关性比血清ACE和支气管肺泡灌洗淋巴细胞之间的相关性更紧密。提示肺泡ACE是肺结节病的另一种生物学标志物,它可能比血清ACE更敏感。

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