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Impact of immunization against SpyCEP during invasive disease with two streptococcal species: Streptococcus pyogenes and Streptococcus equi

机译:两种链球菌:化脓性链球菌和马链球菌在侵袭性疾病中针对SpyCEP免疫的影响

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摘要

Currently there is no licensed vaccine against the human pathogen Streptococcus pyogenes. The highly conserved IL-8 cleaving S. pyogenes cell envelope proteinase SpyCEP is surface expressed and is a potential vaccine candidate. A recombinant N-terminal part of SpyCEP (CEP) was expressed and purified. AntiCEP antibodies were found to neutralize the IL-8 cleaving activity of SpyCEP. CEP-immunized mice had reduced bacterial dissemination from focal S. pyogenes intramuscular infection and intranasal infection. We also identified a functional SpyCEP-homolog protease SeCEP, expressed by the equine pathogen Streptococcus equi, which was able to cleave both human and equine IL-8. CEP-immunized mice also demonstrated reduced bacterial dissemination from S. equi intramuscular infection. Therefore immunization against SpyCEP may provide protection against other streptococci species with homologous proteases.
机译:目前尚无针对人类病原体化脓性链球菌的许可疫苗。高度保守的IL-8裂解化脓性链球菌细胞包膜蛋白酶SpyCEP是表面表达的,并且是潜在的疫苗候选物。表达并纯化了SpyCEP(CEP)的重组N末端部分。发现抗CEP抗体中和SpyCEP的IL-8切割活性。经CEP免疫的小鼠减少了因化脓性链球菌肌肉内感染和鼻内感染引起的细菌传播。我们还鉴定了由马病原体马链球菌表达的功能性SpyCEP-同源蛋白酶SeCEP,它能够裂解人和马IL-8。经CEP免疫的小鼠还显示出减少了马链球菌感染引起的细菌传播。因此,针对SpyCEP的免疫接种可通过同源蛋白酶为其他链球菌提供保护。

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