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Immunoexpression of HBME-1, High Molecular Weight Cytokeratin, Cytokeratin 19, Thyroid Transcription Factor-1, and E-cadherin in Thyroid Carcinomas

机译:甲状腺癌中HBME-1,高分子量细胞角蛋白,细胞角蛋白19,甲状腺转录因子-1和E-钙黏着蛋白的免疫表达

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摘要

To examine the immunohistochemical alterations associated with the histological dedifferentiation of thyroid carcinomas, we performed staining for HBME-1, high molecular weight cytokeratin (HCK), CK 19, thyroid transcription factor-1 (TTF-1) and E-cadherin (E-CD) on 125 various types of thyroid carcinomas. The HBME-1 staining was strong and diffuse in follicular carcinoma (FC), papillary carcinoma (PC), and poorly differentiated carcinoma (PDC), while it was rare in undifferentiated carcinoma (UC) as well as in benign lesions. Strong, diffuse staining for CK19 and HCK was predominantly found in PC, and these markers were not much found in other carcinomas. TTF-1 uniformly stained the tumor cells of all cases of PC, FC and Hurthle cell carcinoma (HC) and 42% of the PDC, while there was only focal staining in one case of the UC. Compared to the strong, diffuse reactivity in the benign lesions, E-CD staining was noted in 67% of PC, 80% of FC, 83% of HC, 58% of PDC and none of the UC. These results suggest that HBME-1 may be a marker for well-differentiated carcinomas while CK19 and HCK are phenotypic markers for papillary carcinoma. The loss or reduced expression of TTF-1 and E-CD may be markers for dedifferentiation.
机译:为了检查与甲状腺癌的组织学去分化相关的免疫组织化学改变,我们对HBME-1,高分子量细胞角蛋白(HCK),CK 19,甲状腺转录因子-1(TTF-1)和E-钙黏着蛋白(E- CD)上的125种甲状腺癌。 HBME-1染色在滤泡癌(FC),乳头状癌(PC)和低分化癌(PDC)中较强且弥散,而在未分化癌(UC)和良性病变中很少见。在PC中主要发现CK19和HCK的强烈,弥漫性染色,而在其他癌中则很少发现这些标记。 TTF-1对所有PC,FC和Hurthle细胞癌(HC)病例和42%的PDC的肿瘤细胞进行了均匀染色,而对一例UC仅进行了局部染色。与良性病变中的强而弥漫的反应性相比,在67%的PC,80%的FC,83%的HC,58%的PDC和所有UC中均未观察到E-CD染色。这些结果表明,HBME-1可能是高分化癌的标志物,而CK19和HCK是乳头状癌的表型标志物。 TTF-1和E-CD的表达缺失或减少可能是去分化的标志。

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