Antiandrogen and Antimicrobial Aspects of Coordination Compounds of Palladium(II), Platinum(II) and Lead(II)

摘要

Synthesis, characterization and antimicrobial activities of an interesting class of biologically potentmacrocyclic complexes have been carried out. All the complexes have been evaluated for their antimicrobialeffects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular spermmorphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails andbiochemical parameters of reproductive organs have been examined and discussed. The resulting biologicallyactive [M(MaLn)(R2)]Cl2 and [Pb(MaLn)(R2)X2] (where, M = PdII or PtII and X = Cl or NO3) type ofcomplexes have been synthesized by the reactions of macrocyclic ligands (MaLn) with metal salts anddifferent diamines in 1:1:1 molar ratio in methanol. Initially the complexes were characterized by elementalanalyses, molecular weight determinations and conductivity measurements. The mode of bonding wasestablished on the basis of IR, 1H NMR, 13C NMR, 195Pt NMR, 207Pb NMR, XRD and electronic spectral studies. The macrocyclic ligand coordinates through the four azomethine nitrogen atoms which are bridgedby benzil moieties. IR spectra suggest that the pyridine nitrogen is not coordinating. The palladium andplatinum complexes exhibit tetracoordinated square-planar geometry, whereas a hexacoordinated octahedralgeometry is suggested for lead complexes.