INCREASED SURVIVAL IN MICE INOCULATED WITH TUMOR CELLS AND TREATED WITH INTERFERON PREPARATIONS

摘要

Repeated administration of potent mouse interferon preparations increased the survival of Balb/c and C 57/B16 mice inoculated with 2,000-3,000 RC19 and EL4 tumor cells. Only 7/188 (3.7%) untreated mice (or mice treated with control preparations) survived more than 22 days after intraperitoneal inoculation of RC19 tumor cells. None survived more than 60 days. In contrast, 101/103 (98%) interferon-treated mice survived beyond 22 days, and sixteen (15%) survived more than 60 days. None of these 16 surviving mice show any sign of tumor at present. Three mice (of the 16) from an early experiment are alive ten months after inoculation of RC19 tumor cells.