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Spectrophotometric Estimation of Ethamsylate and Mefenamic Acid from a Binary Mixture by Dual Wavelength and Simultaneous Equation Methods

机译:双波长和联立方程法分光光度法测定二元混合物中的苯甲酸和苯甲酸

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摘要

Two simple, accurate, economical and reproducible spectrophotometric methods for simultaneous estimation of two-component drug mixture of ethamsylate and mefenamic acid in combined tablet dosage form have been developed. The first developed method involves formation and solving of simultaneous equation using 287.6 nm and 313.2 nm as two wavelengths. Second developed method is based on two wavelength calculation. Two wavelengths selected for estimation of ethamsylate were 274.4 nm and 301.2 nm while that for mefenamic acid were 304.8 nm and 320.4 nm. Both the developed methods obey Beer's law in the concentration ranges employed for the respective methods. The results of analysis were validated statistically and by recovery studies.
机译:已经开发了两种简单,准确,经济和可重现的分光光度法,用于同时估算组合片剂剂型中乙胺磺酸和甲芬那酸的两组分药物混合物。首先开发的方法涉及使用287.6 nm和313.2 nm作为两个波长的联立方程的形成和求解。第二种开发的方法是基于两个波长的计算。选择用于估计乙胺基甲酸酯的两个波长是274.4 nm和301.2 nm,而用于甲芬那酸的波长是304.8 nm和320.4 nm。两种开发的方法在各自方法所采用的浓度范围内均符合比尔定律。分析结果通过统计学和回收率研究进行了验证。

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  • 作者

    Goyal, Anju; Singhvi, I.;

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  • 年度 2008
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  • 原文格式 PDF
  • 正文语种 en
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