首页> 外文OA文献 >Description and validation of a method for simultaneous estimation of effective population size and mutation rate from human population data.
【2h】

Description and validation of a method for simultaneous estimation of effective population size and mutation rate from human population data.

机译:描述和验证一种方法,用于从人群数据中同时估算有效人群大小和突变率。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

A method is presented for utilizing population data on electrophoretic variants of proteins to estimate simultaneously the effective sizes (Ne values) of the populations in question and the rate of mutation resulting in electromorphs at the loci whose products were surveyed. The method is applied to data from 12 relatively unacculturated Amerindian tribes for whom census data and independent estimates of the number of different electrophoretic variants at 27 loci are available. Because of tribal demographic structure, Ne should be less than the current number of reproductive-aged adults. In fact, it is substantially greater for 7 tribes, most likely due to intertribal migration and a recent decrease in tribal size. Estimates of locus mutation rates for the 27 loci vary by more than a factor of 20, with an average of 1.1 x 10(-5) per locus per generation. This latter estimate is in satisfactory agreement with the results of other indirect approaches to the estimation of mutation rates in these tribes but about two times higher than the results of direct estimates based on these same loci in studies on civilized populations. This discrepancy could be due to the above-hypothesized migration and to decreases in tribal size.
机译:提出了一种利用蛋白质电泳变异体上的种群数据来同时估算所研究种群的有效大小(Ne值)和突变位点的方法,该位点在调查其产物的位点产生了电子形态。该方法适用于来自12个相对未经训练的美洲印第安人部落的数据,这些人口普查数据和27个基因座处不同电泳变异体数量的独立估计均可用。由于部落人口结构的原因,Ne应当少于目前的育龄成年人数。实际上,这对于7个部落来说要大得多,这很可能是由于部落间的迁徙和最近部落规模的减少。 27个基因座的基因座突变率估计相差超过20倍,每代每个基因座平均有1.1 x 10(-5)。后一估计与这些部落中突变率的其他间接估计方法的结果令人满意,但比基于这些相同基因座的直接估计结果高出两倍。这种差异可能是由于上述假设的迁徙和部落规模的减少所致。

著录项

  • 作者

    Chakraborty, R; Neel, J V;

  • 作者单位
  • 年度 1989
  • 总页数
  • 原文格式 PDF
  • 正文语种 en
  • 中图分类

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号