首页> 外文OA文献 >The effects of cyclic adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate and theophylline on renin secretion in the isolated perfused kidney of the rat.
【2h】

The effects of cyclic adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate and theophylline on renin secretion in the isolated perfused kidney of the rat.

机译:环状腺苷3',5'-单磷酸和鸟苷3',5'-单磷酸和茶碱对大鼠离体灌注肾脏中肾素分泌的影响。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

1. The influence of cyclic adenosine 3',5'-monophosphate (cyclic AMP), cylic guanosine 3',5'-monophosphate (cyclic GMP) and theophylline on renin secretion was examined in the isolated kidney of the rat perfused with Krebs dextran solution. 2. Neither cyclic AMP (10(-6) to 10(-4) M) nor dibytyryl cyclic AMP (10(-5) M) produced an increase in renin secretion. 3. Cyclic GMP and 8 Br-cyclic GMP caused a small rise in renin secretion in some experiments but this effect was independent of the dose and its physiological significance is uncertain. 4. Theophylline (10(-6) to 10(14) M) caused a significant elevation in renin secretion which was not blocked by (+)-propranolol. Theophylline with cyclic AMP or cyclic GMP did not produce an amplified effect. 5. Despite previous suggestions that cyclic AMP stimulated renin secretion, this could not be confirmed in the present preparation. Since there is no evidence that cyclic AMP or cyclic GMP (or their derivatives, dibutyryl cyclic AMP and 8 Br-cyclic GMP) enter the cells, it will be necessary to study their activity in isolated juxtaglomerular cells to define a possible role.
机译:1.在灌注了克雷布斯葡聚糖的大鼠离体肾脏中,研究了环状腺苷3',5'-单磷酸盐(环状AMP),环状鸟苷3',5'-单磷酸盐(环状GMP)和茶碱对肾素分泌的影响。解。 2.环状AMP(10(-6)至10(-4)M)或二酪基环状AMP(10(-5)M)均未导致肾素分泌增加。 3.在某些实验中,环状GMP和8 Br-环状GMP引起肾素分泌的少量增加,但这种作用与剂量无关,其生理学意义尚不确定。 4.茶碱(10(-6)至10(14)M)导致肾素分泌显着升高,但未被(+)-心得安阻断。具有环AMP或环GMP的茶碱未产生放大作用。 5.尽管先前有关于环状AMP刺激肾素分泌的建议,但目前的制备方法尚不能证实。由于没有证据表明环状AMP或环状GMP(或其衍生物,二丁酰基环状AMP和8 Br环状GMP)进入细胞,因此有必要研究它们在分离的肾小球细胞中的活性以定义可能的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号