Bioactive Compounds In The Prevention Of Cancer, Mechanisms Of Action

摘要

Epidemiological studies have consistently shown that increased consumption of fruits and vegetables is associated with reduced risk of various chronic diseases including cardiovascular diseases, hypertension, diabetes and cancers. Phytochemicals in fruits and vegetables have been identified as the primary contributors to these health benefits. However, the molecular mechanisms of the anticarcinogenic effects of fruits and vegetables are not completely understood. Previous works from our lab clearly showed the antiproliferative activity of quercetin-3-glucoside towards human breast cancer MCF-7 cells. In the project investigating the mechanism of action of the quercetin-3-glucoside, my work demonstrated that quercetin-3-glucoside inhibits MCF-7 cell proliferation by activating p38/MAPK pathway through targeting ASK1. It also induces cell apoptosis via p53-dependent pathway. In conclusion, we demonstrated that quercetin-3-glucoside exerted anticarcinogenic effects via counteracting antiproliferation and apoptosis induction. These data may be important in further understandings of the protective effects of fruits and vegetables against related cancers.