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Comparison of Efficacy, Side Effects, and Cost of Isoxasolines and Ivermectin Against Generalized Canine Demodicosis

机译:异恶唑啉和伊维菌素治疗普通犬蠕形螨病的功效,副作用和费用的比较

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摘要

Demodex canis mites are found in the normal skin microbiota of most dogs, but can result in canine demodicosis if the number of mites dramatically increases due to underlying disease, immunosurpression, genetic defect, stress, or breed association. Treating generalized Demodectic mange often requires high owner compliance over a potentially long period of time, especially when using ivermectin. Recent studies have revealed that a class of insecticides known as isoxasolines provide a better alternative for treatment of generalized demodicosis, specifically afoxolaner (NexGard®), fluralaner (Bravecto™), and sarolaner (Simparica™). This review compares the efficacy, side effects, and cost of isoxasolines to ivermectin in efforts to aid owners and veterinarians in choosing an effective, yet safe and lost-cost treatment option. Although additional studies are needed, fluralaner appears to be highly efficacious and the safest and cheapest treatment option for generalized canine demodicosis, while ivermectin appeared to be the least preferred treatment option presently, a major factor being toxicity.
机译:蠕形螨犬螨存在于大多数犬的正常皮肤微生物群中,但是如果螨的数量由于潜在疾病,免疫抑制,遗传缺陷,压力或品种关联而急剧增加,则可能导致犬蠕形螨病。治疗泛滥的蠕形螨病通常需要在可能较长的时间内保持较高的主人依从性,尤其是在使用伊维菌素时。最近的研究表明,一类称为异恶唑啉的杀虫剂为广泛的蠕形螨病提供了更好的替代品,特别是afoxolaner(NexGard®),fluralaner(Bravecto™)和sarolaner(Simparica™)。这篇综述比较了异恶唑啉对伊维菌素的疗效,副作用和成本,以帮助业主和兽医选择有效,安全且成本低廉的治疗方案。尽管还需要进行更多的研究,但氟尿烷似乎对全身犬蠕形螨病非常有效,也是最安全,最便宜的治疗选择,而伊维菌素似乎是目前最不受欢迎的治疗选择,主要因素是毒性。

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    Leinart Linzey Barbara;

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  • 年度 2017
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