Kinetic Resolution of Primary Amines via Enantioselective N-Acylation with Acyl Chlorides in the Presence of Supramolecular Cyclodextrin Nanocapsules

摘要

The non-enzymatic kinetic resolution of primary amines via enantioselective N-acylation with acyl chlorides was accomplished for the first time by using the selective sequestration of one enantiomer within a supramolecular cyclodextrin (CD) nanocapsule in nonpolar solvents. In addition, the first example of a crystalline structure for an inclusion complex between an acyl chloride and a CD derivative is reported.